{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:52:25Z","timestamp":1791420745821,"version":"4.3.3"},"reference-count":76,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>In advanced cancer, associations among changes in body composition, cardiac wasting and prior cardiotoxic anticancer therapy have not been investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      Using bioelectrical impedance analysis (BIA), body composition was measured in 206 patients with mostly advanced cancer without known cardiovascular disease or infection (stage III\/IV: 84%, prior cardiotoxic anticancer therapy: 55%). Left ventricular (LV) mass was assessed by transthoracic echocardiography and grouped by presence of cardiac wasting according to previously established sex\u2010specific thresholds for LV mass adjusted for height\n                      <jats:sup>2<\/jats:sup>\n                      (&lt;61\u2009g\/m\n                      <jats:sup>2<\/jats:sup>\n                      for women, &lt;57\u2009g\/m\n                      <jats:sup>2<\/jats:sup>\n                      for men). BIA measurements (indexed to height\n                      <jats:sup>2<\/jats:sup>\n                      ) included fat mass index (FMI), fat\u2010free mass index (FFMI), skeletal muscle mass index (SMMI), visceral fat index (VFI), total body water index (TBWI) and extracellular water index (ECWI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Patients with cancer and cardiac wasting (\n                      <jats:italic>n<\/jats:italic>\n                      = 88) were younger (57\u00b115 vs 62\u00b113\u2009years) and more often women (68% vs 29%) compared to those without cardiac wasting (\n                      <jats:italic>n<\/jats:italic>\n                      = 118). Patients with cardiac wasting had significantly lower FMI (\u221212%), FFMI (\u221214%), SMMI (\u221216%), VFI (\u221246%), TBWI (\u221213%) and ECWI (\u221214%). For women, FFMI was significantly associated with LV mass\/height\n                      <jats:sup>2<\/jats:sup>\n                      (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.41) and VFI for men (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.40). In the multivariable linear regression analysis, FFMI was the strongest significant predictor of cardiac wasting, with no significant interaction by sex or previous cardiotoxic therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>Cardiac wasting in advanced cancer is associated with lower FFMI and VFI independent of prior cardiotoxic therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70639","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:21:01Z","timestamp":1791418861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of altered body composition with cardiac wasting in cancer with and without cardiotoxic therapy"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8481-337X","authenticated-orcid":false,"given":"Sara","family":"Hadzibegovic","sequence":"first","affiliation":[{"name":"Charit\u00e9\u2014University Medicine Berlin Corporate Member of Free University Berlin and Humboldt\u2010University Berlin  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Berlin  Berlin Germany"},{"name":"Deutsches Herzzentrum der Charit\u00e9 Department of Cardiology, Angiology and Intensive Care Medicine CBF  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan L.","family":"Hella","sequence":"additional","affiliation":[{"name":"Charit\u00e9\u2014University Medicine Berlin Corporate Member of Free University Berlin and Humboldt\u2010University Berlin  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), partner site Berlin  Berlin Germany"},{"name":"Deutsches Herzzentrum der 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