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Recent studies reporting gain\u2010of\u2010function TRPM3 mutations in patients with neurodevelopmental and epilepsy\u2010associated disorders suggest a previously unrecognized role of this channel in the brain. However, the function of TRPM3 in neurons of the brain remains largely unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental approach<\/jats:title>\n                    <jats:p>\n                      Using a battery of\n                      <jats:italic>in vivo<\/jats:italic>\n                      and\n                      <jats:italic>in vitro<\/jats:italic>\n                      electrophysiological and histological experiments, we studied the effect of TRPM3 channel on amygdala\u2010related functions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key results<\/jats:title>\n                    <jats:p>Here, we identify TRPM3 expression in excitatory neurons of the lateral nucleus of the amygdala (LA), a brain region critical for fear learning also implicated in neuropsychiatric and epileptic disorders. We demonstrate that TRPM3 is functionally active in LA neurons and regulates their intrinsic electrophysiological properties. Consistent with this role, genetic ablation of TRPM3 in mice impairs fear memory formation. Moreover, in a kainic acid\u2010induced epilepsy model, loss of TRPM3 reduces seizure severity, whereas pharmacological activation of the channel exacerbates seizure phenotypes. Finally, we demonstrate the presence of TRPM3 transcripts in neurons of the human LA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and implications<\/jats:title>\n                    <jats:p>Together, these findings uncover a central role for TRPM3 in amygdala function and identify this ion channel as a modulator of fear memory and seizure susceptibility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70669","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:46:19Z","timestamp":1789951579000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TRPM3 regulates fear memory encoding and seizure susceptibility in the lateral amygdala"],"prefix":"10.1111","author":[{"given":"Attila","family":"Gy\u00e9resi","sequence":"first","affiliation":[{"name":"Institute of Physiology, Medical School University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mundrucz","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Medical School University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1t\u00e9","family":"De\u00e1k","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Medical School University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9la","family":"Kecsk\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Medical School University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Borb\u00e9ly","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Medical School University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikt\u00f3ria","family":"Kormos","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Medical School University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs","family":"Gaszner","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orsolya","family":"Mih\u00e1ly","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Borb\u00e1la Hospital  Tatab\u00e1nya Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs Istv\u00e1n","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Medical School University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2502-0409","authenticated-orcid":false,"given":"Joris","family":"Vriens","sequence":"additional","affiliation":[{"name":"Laboratory of Ion Channel Research, Biomedical Sciences Group, Department of Cellular and Molecular Medicine, VIB\u2010KU Leuven Center for Brain &amp; Disease Research KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Voets","sequence":"additional","affiliation":[{"name":"Laboratory of Ion Channel Research, Biomedical Sciences Group, Department of Cellular and Molecular Medicine, VIB\u2010KU Leuven Center for Brain &amp; Disease Research KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erzs\u00e9bet","family":"K\u00f6vesdi","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Medical School University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"Kecsk\u00e9s","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Medical School University of P\u00e9cs  P\u00e9cs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70231"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2007.11.011"},{"key":"e_1_2_12_4_1","unstructured":"Biohaven. 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