{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:48:06Z","timestamp":1791877686412,"version":"4.3.4"},"reference-count":115,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GO 766\/22\u20103"],"award-info":[{"award-number":["GO 766\/22\u20103"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GO766\/25\u20101"],"award-info":[{"award-number":["GO766\/25\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GO766\/26\u20101"],"award-info":[{"award-number":["GO766\/26\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KA 5422\/1\u20103"],"award-info":[{"award-number":["KA 5422\/1\u20103"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["END611955"],"award-info":[{"award-number":["END611955"]}],"id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Coordinated peristalsis between the renal pelvis and ureter is critical for effective urine transport. However, intraluminal pressure impact on upper urinary tract (UUT) contractility and pharmacologic responsiveness remains poorly understood due to absence of suitable investigative methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      This study introduces the first application of high\u2010resolution pressure myography to UUT, establishing a novel\n                      <jats:italic>ex vivo<\/jats:italic>\n                      platform enabling simultaneous, intraluminal pressure\u2010controlled local measurement of renal pelvic contraction frequency and amplitude and ureteral inner diameter, outer diameter, and wall thickness. To define contribution of specific Ca\n                      <jats:sup>2+<\/jats:sup>\n                      signaling pathways, we pharmacologically examined Ca\n                      <jats:sub>v<\/jats:sub>\n                      1.2 L\u2010type, Ca\n                      <jats:sub>v<\/jats:sub>\n                      3.x T\u2010type, and ryanodine receptor channels, as well as sarco\/endoplasmic reticulum Ca\n                      <jats:sup>2+<\/jats:sup>\n                      \u2010ATPase (SERCA) and neuronal involvement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Elevating intraluminal pressure from 4 to 20\u2009mmHg increased renal pelvic contraction frequency, while amplitude markedly decreased. Ureteral wall thinning was the main structural adaptation. Nifedipine reduced renal pelvic contraction amplitude and frequency and suppressed ureter peak contraction, all with reduced efficacy under high\u2010pressure conditions. Ni\n                      <jats:sup>2+<\/jats:sup>\n                      affected renal pelvic contractility only at high concentrations and had no effect on ureteral dynamics. Ryanodine did not alter measured parameters, and Na\n                      <jats:sup>+<\/jats:sup>\n                      and N\u2010type Ca\n                      <jats:sup>2+<\/jats:sup>\n                      channels were not involved.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>\n                      High\u2010resolution pressure myography reveals pressure\u2010dependent local contractile and geometric responses in UUT, including altered contraction dynamics, ureteral geometric remodeling, and specific Ca\n                      <jats:sup>2+<\/jats:sup>\n                      channel contributions. Ca\n                      <jats:sub>v<\/jats:sub>\n                      1.2 channels modulate both amplitude and frequency, with wall thinning as principal acute structural adaptation. Reduced drug efficacy at high pressure highlights necessity to investigate possible pressure\u2010adapted therapies in obstructive uropathy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70695","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:13:42Z","timestamp":1791875622000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High\u2010resolution pressure myography reveals pressure\u2010dependent local contractile and geometric dynamics in the renal pelvis and ureter"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9084-8942","authenticated-orcid":false,"given":"Zhugang","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Biomedicine Guizhou University Medical College  Guiyang China"},{"name":"Department of Internal Medicine and Geriatrics University Medicine Greifswald  Greifswald Germany"},{"name":"Department of Urology Guizhou Provincial People's Hospital  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9033-9430","authenticated-orcid":false,"given":"Qidi","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Geriatrics University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7988-6521","authenticated-orcid":false,"given":"Liming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Geriatrics University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2797-1934","authenticated-orcid":false,"given":"Maik","family":"Gollasch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Geriatrics University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6472-971X","authenticated-orcid":false,"given":"Dmitry","family":"Tsvetkov","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Geriatrics University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2372-9833","authenticated-orcid":false,"given":"Rong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Urology Guizhou Provincial People's Hospital  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5808-0304","authenticated-orcid":false,"given":"S. R. Wayne","family":"Chen","sequence":"additional","affiliation":[{"name":"Libin Cardiovascular Institute, Department of Physiology and Pharmacology University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1894-3253","authenticated-orcid":false,"given":"Gang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Urology Shenzhen University Affiliated Sixth Hospital  Shenzhen China"},{"name":"Pan\u2010Vascular Research Group Shenzhen University Affiliated Sixth Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8387-2047","authenticated-orcid":false,"given":"Guangheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Urology Guizhou Provincial People's Hospital  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4785-6530","authenticated-orcid":false,"given":"Mario","family":"Kassmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Geriatrics University Medicine Greifswald  Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70230"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70234"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70235"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70231"},{"issue":"7","key":"e_1_2_13_6_1","first-page":"690","article-title":"Immunohistochemical evaluation of Cajal\u2010like cells and Caveolin\u20101 levels at ureteropelvic junction obstruction","volume":"72","author":"Bayrak O.","year":"2019","journal-title":"Archivos Espa\u00f1oles de Urolog\u00eda"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2005.11.002"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/35036035"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0041-008x(05)80018-3"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-5895-1_4"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp021054"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-008-9123-1"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.2218\/gtopdb\/F80\/2025.3"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mop.0000193287.56528.a4"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-003-1074-8"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496041"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2024.102845"},{"issue":"3","key":"e_1_2_13_18_1","first-page":"233","article-title":"Urodynamics of the upper urinary tract","volume":"14","author":"Constantinou C. E.","year":"1976","journal-title":"Investigative Urology"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01936991"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1981.241.5.R412"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022070"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.17441"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-007-0314-3"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091750203"},{"issue":"1","key":"e_1_2_13_25_1","first-page":"129","article-title":"The musculature of the human renal calices, pelvis and upper ureter","volume":"135","author":"Dixon J. S.","year":"1982","journal-title":"Journal of Anatomy"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2009.08576.x"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043061"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.138982"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/pl00006605"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/19336950.2019.1688910"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13134"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP276923"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2631-4"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00308.2007"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.02.045"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1978.tb02244.x"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(82)90359-4"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1446-x"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1980.238.3.F205"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.3.C842"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.83.11.1104"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP278888"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqac041"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007010200"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.304056"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305736"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-016-1930-6"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI70025"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2007.038240"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-013-0363-z"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.483"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-237289"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12444"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1989.sp017565"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2017090951"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402388101"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2015.0251"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)64420-3"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-015-1114-4"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M510197200"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.23968"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.104220"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010090"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0867n.x"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.211br.x"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.83.220"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12612"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018033"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1113\/eph8702290"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1998.tb02357.x"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-5895-1_3"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704609"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.137034"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707535"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.116855"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00300025"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(99)77134-1"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15178"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1410565"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1341220"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-8673.1995.tb00348.x"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.233"},{"issue":"3","key":"e_1_2_13_83_1","first-page":"157","article-title":"Initiation and propagation of stimulus from the renal pelvic pacemaker in pig kidney","volume":"19","author":"Morita T.","year":"1981","journal-title":"Investigative Urology"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)45551-0"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.35.346"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1556\/APhysiol.96.2009.4.2"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2020.0849"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00058.2010"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.5.4_pt_2.ii18"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015030318"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.11.048"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327116646840"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2929-0_19"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.302882"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.43"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000176818.71501.93"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1990.259.6.F888"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-002-0941-7"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000097401.03293.f0"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365598809180800"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06568.x"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.50.597"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00103.2012"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701711"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.276683"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002040050411"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23338"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(81)90112-x"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01021.2020"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-4096.2001.woodward.2578.x"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.174834"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00168637"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00371106"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2406"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28020784"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70695","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.70695","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:13:44Z","timestamp":1791875624000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":115,"alternative-id":["10.1111\/bph.70695"],"URL":"https:\/\/doi.org\/10.1111\/bph.70695","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]},"assertion":[{"value":"2025-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"bph.70695"}}