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TASK1 potassium channels represent a promising atrial\u2010selective antiarrhythmic target, but their relevance in horses has not been established. To characterize equine TASK1 (eqTASK1) channels regarding structural conservation, electrophysiological function, pharmacological sensitivity, cardiac expression pattern and\n                      <jats:italic>in vivo<\/jats:italic>\n                      electrophysiological effects of TASK1 inhibition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      Sixteen horses killed for non\u2010cardiovascular reasons, of which 10 horses used for tissue harvesting and six horses for\n                      <jats:italic>in vivo<\/jats:italic>\n                      testing. Functional and pharmacological properties of eq TASK1 and human (hTASK1) channels were assessed in\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Xenopus laevis<\/jats:italic>\n                      <\/jats:styled-content>\n                      oocytes using two\u2010electrode voltage clamp recordings. Cardiac expression of eqTASK1 was analysed by qRT\u2010PCR and immunoblotting, while\n                      <jats:italic>in vivo<\/jats:italic>\n                      electrophysiological studies were performed in anaesthetized horses before and after intravenous ketodoxapram administration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      EqTASK1 and h TASK1 channels demonstrated high structural conservation, comparable potassium\u2010selective background currents and preserved pharmacological sensitivity with species\u2010dependent differences in potency. EqTASK1 expression was strongly enriched in atrial and nodal tissue, whereas ventricular expression was minimal.\n                      <jats:italic>In vivo<\/jats:italic>\n                      administration of ketodoxapram significantly prolonged atrial effective refractory periods from 275\u2009\u00b1\u200954 to 418\u2009\u00b1\u200994\u2009ms without significant changes in heart rate or atrioventricular conduction parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>\n                      EqTASK1 channels are highly conserved with human orthologs and display pronounced atrial\u2010predominant cardiac expression.\n                      <jats:italic>In vivo<\/jats:italic>\n                      TASK1 inhibition prolongs atrial refractoriness in horses, supporting TASK1 as a translational atrial\u2010selective antiarrhythmic target in both human and veterinary medicine.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70703","type":"journal-article","created":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:35:29Z","timestamp":1792827329000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the TASK1 potassium channel in equine atrial myocardium as a potential treatment target for atrial fibrillation"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3462-0749","authenticated-orcid":false,"given":"Lize\u2010Maria","family":"Verhaeghe","sequence":"first","affiliation":[{"name":"Equine Cardioteam Ghent, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasa","family":"J\u00e1vorszky","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg Heidelberg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg\/Mannheim, University of Heidelberg  Heidelberg Germany"},{"name":"Department of Urology Jahn Ferenc South\u2010Pest Hospital  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6764-2970","authenticated-orcid":false,"given":"Manuel","family":"Kraft","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg Heidelberg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg\/Mannheim, University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8168-0025","authenticated-orcid":false,"given":"Felix","family":"Wiedmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg Heidelberg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg\/Mannheim, University of Heidelberg  Heidelberg Germany"},{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen G\u00f6ttingen, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Lower Saxony, University of Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederike Marie","family":"Weitkamp","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Pneumology, University Medical Center G\u00f6ttingen G\u00f6ttingen, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Lower Saxony, University of Goettingen  Goettingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8129-2006","authenticated-orcid":false,"given":"Annelies","family":"Decloedt","sequence":"additional","affiliation":[{"name":"Equine Cardioteam Ghent, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0165-5215","authenticated-orcid":false,"given":"Glenn","family":"Van Steenkiste","sequence":"additional","affiliation":[{"name":"Equine Cardioteam Ghent, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5191-5241","authenticated-orcid":false,"given":"Gunther","family":"van Loon","sequence":"additional","affiliation":[{"name":"Equine Cardioteam Ghent, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5897-237X","authenticated-orcid":false,"given":"Constanze","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Pneumology, University Hospital Heidelberg Heidelberg, Germany; 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