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It may also occur in response to resistance in blood flow due to various insults on the heart and vessels that accumulate with age. The heart can only compensate to this increase in workload to a certain extent without losing its functional architecture, ultimately resulting in heart failure. Many genes have been implicated in cardiac hypertrophy, however none have been shown conclusively to be responsible for pathological cardiac hypertrophy. <jats:styled-content style=\"fixed-case\">MicroRNAs<\/jats:styled-content> offer an alternative mechanism for cellular regulation by altering gene expression. Since 1993 when the function of a non\u2010coding <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> sequence was first discovered in the model organism <jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>aenorhabditis elegans<\/jats:italic>, many <jats:styled-content style=\"fixed-case\">microRNAs<\/jats:styled-content> have been implicated in having a central role in numerous physiological and pathological cellular processes. The level of control these antisense oligonucleotides offer can often be exploited to manipulate the expression of target genes. Moreover, altered levels of <jats:styled-content style=\"fixed-case\">microRNAs<\/jats:styled-content> can serve as diagnostic biomarkers, with the prospect of diagnosing a disease process as early as during foetal life. Therefore, it is vital to ascertain and investigate the function of <jats:styled-content style=\"fixed-case\">microRNAs<\/jats:styled-content> that are involved in heart development and subsequent ventricular remodelling. Here we present an overview of the complicated network of <jats:styled-content style=\"fixed-case\">microRNAs<\/jats:styled-content> and their target genes that have previously been implicated in cardiogenesis and hypertrophy. It is interesting to note that <jats:styled-content style=\"fixed-case\">microRNAs<\/jats:styled-content> in both of these growth processes can be of possible remedial value to counter a similar disease pathophysiology.<\/jats:p>","DOI":"10.1111\/brv.12283","type":"journal-article","created":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T06:12:48Z","timestamp":1464761568000},"page":"1314-1331","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Micro<scp>RNA<\/scp>s in a hypertrophic heart: from foetal life to adulthood"],"prefix":"10.1111","volume":"92","author":[{"given":"Shahzad","family":"Sadiq","sequence":"first","affiliation":[{"name":"School of Medicine, Faculty of Health Deakin University  75 Pigdons Road Waurn Ponds Victoria 3216 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamsyn M.","family":"Crowley","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Health Deakin University  75 Pigdons Road Waurn Ponds Victoria 3216 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi J.","family":"Charchar","sequence":"additional","affiliation":[{"name":"School of Health Sciences Faculty of Science and Technology, Federation University  Ballarat Victoria 3353 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Sanigorski","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Health Deakin University  75 Pigdons Road Waurn Ponds Victoria 3216 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Lewandowski","sequence":"additional","affiliation":[{"name":"School of Medicine, Faculty of Health Deakin University  75 Pigdons Road Waurn Ponds Victoria 3216 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.74.4.555"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200402033"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2012.59"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu180"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07242"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70072-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00045-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206432109"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.04.005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.7.862"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.304185"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11919"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb1167"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1013555107"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-5107-5_9"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2014.08.011"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36154"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.1092"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1582"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1885-5857(06)60796-2"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1207605109"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.300658"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1725"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1725"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710228105"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03868"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050536"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.192872"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.769984"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.110.082784"},{"key":"e_1_2_9_33_1","first-page":"381","article-title":"Mechanisms of control of microRNA biogenesis","volume":"148","author":"Davis\u2010Dusenbery B. 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