{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:50:22Z","timestamp":1791946222491,"version":"4.3.4"},"reference-count":349,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T00:00:00Z","timestamp":1487548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["11130033"],"award-info":[{"award-number":["11130033"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biological Reviews"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title><jats:styled-content style=\"fixed-case\">ABSTRACT<\/jats:styled-content><\/jats:title><jats:p>Over 25\u2009years have passed since peroxisome proliferators\u2010activated receptors (<jats:styled-content style=\"fixed-case\">PPARs<\/jats:styled-content>), were first described. Like other members of the nuclear receptors superfamily, <jats:styled-content style=\"fixed-case\">PPARs<\/jats:styled-content> have been defined as critical sensors and master regulators of cellular metabolism. Recognized as ligand\u2010activated transcription factors, they are involved in lipid, glucose and amino acid metabolism, taking part in different cellular processes, including cellular differentiation and apoptosis, inflammatory modulation and attenuation of acute and chronic neurological damage <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic>. Interestingly, <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content> activation can simultaneously reprogram the immune response, stimulate metabolic and mitochondrial functions, promote axonal growth, induce progenitor cells to differentiate into myelinating oligodendrocytes, and improve brain clearance of toxic molecules such as \u03b2\u2010amyloid peptide. Although the molecular mechanisms and cross\u2010talk with different molecular pathways are still the focus of intense research, <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content>s are considered potential therapeutic targets for several neuropathological conditions, including degenerative disorders such as <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lzheimer's, <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>arkinson's and <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>untington's disease. This review considers recent advances regarding <jats:styled-content style=\"fixed-case\">PPARs<\/jats:styled-content>, as well as new <jats:styled-content style=\"fixed-case\">PPAR<\/jats:styled-content> agonists. We focus on the mechanisms behind the neuroprotective effects exerted by <jats:styled-content style=\"fixed-case\">PPARs<\/jats:styled-content> and summarise the roles of <jats:styled-content style=\"fixed-case\">PPARs<\/jats:styled-content> in different pathologies of the central nervous system, especially those associated with degenerative and inflammatory mechanisms.<\/jats:p>","DOI":"10.1111\/brv.12320","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T16:17:47Z","timestamp":1487693867000},"page":"2046-2069","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":122,"title":["<scp>PPARs<\/scp> in the central nervous system: roles in neurodegeneration and neuroinflammation"],"prefix":"10.1111","volume":"92","author":[{"given":"Juan M.","family":"Zolezzi","sequence":"first","affiliation":[{"name":"Centro de Envejecimiento y Regeneraci\u00f3n (CARE\u2010UC) P. Catholic University of Chile  PO Box 114\u2010D 8331150 Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel J.","family":"Santos","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biol\u00f3gicas, Departamento de Biolog\u00eda Celular y Molecular Pontificia Universidad Cat\u00f3lica de Chile  Alameda 340 8331150 Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sussy","family":"Bast\u00edas\u2010Candia","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias, Departamento de Biolog\u00eda Universidad de Tarapac\u00e1  Gral. Vel\u00e1squez 1775 1000007 Arica Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Pinto","sequence":"additional","affiliation":[{"name":"Centro de Envejecimiento y Regeneraci\u00f3n (CARE\u2010UC) P. Catholic University of Chile  PO Box 114\u2010D 8331150 Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Godoy","sequence":"additional","affiliation":[{"name":"Centro de Envejecimiento y Regeneraci\u00f3n (CARE\u2010UC) P. Catholic University of Chile  PO Box 114\u2010D 8331150 Santiago Chile"},{"name":"Facultad de Ciencias Biol\u00f3gicas, Departamento de Biolog\u00eda Celular y Molecular Pontificia Universidad Cat\u00f3lica de Chile  Alameda 340 8331150 Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nibaldo C.","family":"Inestrosa","sequence":"additional","affiliation":[{"name":"Centro de Envejecimiento y Regeneraci\u00f3n (CARE\u2010UC) P. Catholic University of Chile  PO Box 114\u2010D 8331150 Santiago Chile"},{"name":"Facultad de Ciencias Biol\u00f3gicas, Departamento de Biolog\u00eda Celular y Molecular Pontificia Universidad Cat\u00f3lica de Chile  Alameda 340 8331150 Santiago Chile"},{"name":"Faculty of Medicine, Centre for Healthy Brain Ageing, School of Psychiatry University of New South Wales  Avoca Street Randwick NSW 2031 Sydney Australia"},{"name":"Centro de Excelencia en Biomedicina de Magallanes (CEBIMA) Universidad de Magallanes  PO Box 113\u2010D, Avenida Bulnes 01855 6210427 Punta Arenas Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2010.12.018"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119870"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8352-z"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200000001-00008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.2.185"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2005.02.003"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006930513476"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(96)05854-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1141448"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2174\/187153006776056620"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61349-9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000256294.46009.29"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90015-O"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612822666151223103038"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.50.35881"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20624"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90201-5"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.01.026"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2800249"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1200175"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/864140"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.06.019"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.05.035"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5198-13.2014"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.03.029"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(13)70009-9"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0341341"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.10.028"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.1.8536636"},{"key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1210\/endo.139.6.6049","article-title":"Differential expression of peroxisome proliferator\u2010activated receptor \u2013alpha, \u2010beta, and \u2010gamma during rat embryonic development","volume":"139","author":"Braissant O.","year":"1998","journal-title":"Endocrinology"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001854"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00990.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2007.04.018"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.10.006"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.16.10811"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1222646"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-012-9342-7"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/689181"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2015.1058160"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-3735fje"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/10409230701340019"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720508784533321"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.07.029"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2012.11.011"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.294.5548.1866"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.0216"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4628"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.05.019"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2013.06.004"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2013.12.003"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09291"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705656200"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2005.06.005"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(200005)22:5<442::AID-BIES6>3.0.CO;2-Q"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920207783769512"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2005.11.049"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.161.2.978"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-02-00558.2000"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.14.6065-6076.2005"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-015-9627-8"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1217697"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.12.6806"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.6.2795"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2004.10.004"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.107.041475"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0605341"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.123265"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.05.041"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2617-07.2007"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.033787"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.11.016"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64595"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02210.x"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109409200"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.20.5.649"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20787"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4003"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00464"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2004.11.010"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90031-7"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2010.06.006"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.05.002"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv477"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3283939"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2005.12.002"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108473200"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.9.4312"},{"key":"e_1_2_6_89_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.3233\/JAD-140389","article-title":"Impact of metabolic syndrome on cognitive decline in older age: protective or harmful, where is the pitfall?","volume":"41","author":"Frisardi V.","year":"2014","journal-title":"Journal of Alzheimer's Disease"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-12-82"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.07.018"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700447200"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2003.11.001"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03803.x"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.229"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.03.003"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/415187a"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.506394"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001282"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.016"},{"key":"e_1_2_6_101_1","first-page":"12","article-title":"Signaling pathway cross talk in Alzheimer's disease","volume":"28","author":"Godoy J. A.","year":"2014","journal-title":"Cell Communication and Signaling"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8645-5"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1159\/000318845"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.167"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12213"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.10.4653"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20050964"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/0027-5107(95)00136-0"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(92)90182-J"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2646"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1998.tb00136.x"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2101"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25857"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.2.1241"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720511796391935"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M910350199"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001297200"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.09.009"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21289"},{"key":"e_1_2_6_120_1","doi-asserted-by":"crossref","first-page":"6862","DOI":"10.1523\/JNEUROSCI.20-18-06862.2000","article-title":"Peroxisome proliferator\u2010activated receptor\u2010gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo","volume":"20","author":"Heneka M. T.","year":"2000","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2007.04.016"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0586"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-010-0438-z"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28449E"},{"key":"e_1_2_6_125_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5497.1768"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1114529"},{"key":"e_1_2_6_127_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-188607"},{"key":"e_1_2_6_128_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-121624"},{"key":"e_1_2_6_129_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0222"},{"key":"e_1_2_6_130_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-120397"},{"key":"e_1_2_6_131_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.yexcr.2004.09.032","article-title":"Peroxisome proliferator\u2010activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta\u2010amyloid neurodegeneration: role of Wnt signaling","volume":"304","author":"Inestrosa N. C.","year":"2005","journal-title":"Experimental Cell Research"},{"key":"e_1_2_6_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2003.09.001"},{"key":"e_1_2_6_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/347645a0"},{"key":"e_1_2_6_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1474"},{"key":"e_1_2_6_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2012.10.006"},{"key":"e_1_2_6_136_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.19.9.2094"},{"key":"e_1_2_6_137_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-3-24"},{"key":"e_1_2_6_138_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.8.5646"},{"key":"e_1_2_6_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.04.010"},{"key":"e_1_2_6_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/34184"},{"key":"e_1_2_6_141_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12190"},{"key":"e_1_2_6_142_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050500"},{"key":"e_1_2_6_143_1","doi-asserted-by":"publisher","DOI":"10.2741\/2802"},{"key":"e_1_2_6_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/3242"},{"key":"e_1_2_6_145_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.060074"},{"key":"e_1_2_6_146_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6223"},{"key":"e_1_2_6_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0366-5"},{"key":"e_1_2_6_148_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-009-1511-8"},{"key":"e_1_2_6_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2006.40"},{"key":"e_1_2_6_150_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2013.54.3.545"},{"key":"e_1_2_6_151_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/574180"},{"key":"e_1_2_6_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2012.08.004"},{"key":"e_1_2_6_153_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205054367883"},{"key":"e_1_2_6_154_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.15.7355"},{"key":"e_1_2_6_155_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.9.4318"},{"key":"e_1_2_6_156_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042981"},{"key":"e_1_2_6_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2004.12.014"},{"key":"e_1_2_6_158_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57867"},{"key":"e_1_2_6_159_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2002-0258"},{"key":"e_1_2_6_160_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3432-04.2004"},{"key":"e_1_2_6_161_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr1204890"},{"key":"e_1_2_6_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61514-1"},{"key":"e_1_2_6_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.04.006"},{"key":"e_1_2_6_164_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720507780362092"},{"key":"e_1_2_6_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(01)00296-2"},{"key":"e_1_2_6_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(02)00735-0"},{"key":"e_1_2_6_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(00)00416-0"},{"key":"e_1_2_6_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05139.x"},{"key":"e_1_2_6_169_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.6.2043"},{"key":"e_1_2_6_170_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.6.8834"},{"key":"e_1_2_6_171_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1087344"},{"key":"e_1_2_6_172_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200743200"},{"key":"e_1_2_6_173_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00569.2011"},{"key":"e_1_2_6_174_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.6.3012"},{"key":"e_1_2_6_175_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.6.3406"},{"key":"e_1_2_6_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2013.192"},{"key":"e_1_2_6_177_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.13.4699-4707.2000"},{"key":"e_1_2_6_178_1","first-page":"5","article-title":"How do soluble oligomers of amyloid beta\u2010protein impair hippocampal synaptic plasticity?","volume":"4","author":"Li S.","year":"2010","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"e_1_2_6_179_1","first-page":"2743","article-title":"Effects of telmisartan on the level of A\u03b21\u201042, interleukin\u20101\u03b2, tumor necrosis factor \u03b1 and cognition in hypertensive patients with Alzheimer's disease","volume":"92","author":"Li W.","year":"2012","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_6_180_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmr007"},{"key":"e_1_2_6_181_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.29.040189.001045"},{"key":"e_1_2_6_182_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.9.5790"},{"key":"e_1_2_6_183_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-014-0229-9"},{"key":"e_1_2_6_184_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl066"},{"key":"e_1_2_6_185_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5268-11.2012"},{"key":"e_1_2_6_186_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.6.3.329"},{"key":"e_1_2_6_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90200-7"},{"key":"e_1_2_6_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90199-X"},{"key":"e_1_2_6_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3229"},{"key":"e_1_2_6_190_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr148"},{"key":"e_1_2_6_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.02.017"},{"key":"e_1_2_6_192_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834f043b"},{"key":"e_1_2_6_193_1","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/93416"},{"key":"e_1_2_6_194_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006863123068"},{"key":"e_1_2_6_195_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006239"},{"key":"e_1_2_6_196_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn400100f"},{"key":"e_1_2_6_197_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21751"},{"key":"e_1_2_6_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-0760(98)00144-7"},{"key":"e_1_2_6_199_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/63.9.901"},{"key":"e_1_2_6_200_1","doi-asserted-by":"publisher","DOI":"10.1007\/1-4020-5688-5_5"},{"key":"e_1_2_6_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(94)90707-2"},{"key":"e_1_2_6_202_1","first-page":"435","article-title":"The hepatic effects of hypolipidemic drugs (colfibrate, nafenopin, tibric acid, and ,y\u201014,643) on hepatic peroxisomes and peroxisome\u2010associated enzymes","volume":"90","author":"Moody D. E.","year":"1978","journal-title":"The American Journal of Pathology"},{"key":"e_1_2_6_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.08.007"},{"key":"e_1_2_6_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.08.064"},{"key":"e_1_2_6_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.04.051"},{"key":"e_1_2_6_206_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-012-0032-x"},{"key":"e_1_2_6_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.01.025"},{"key":"e_1_2_6_208_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006338"},{"key":"e_1_2_6_209_1","doi-asserted-by":"crossref","first-page":"8071","DOI":"10.1074\/jbc.272.12.8071","article-title":"Identification, characterization, and tissue distribution of human peroxisome proliferator\u2010activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and activation with retinoid X receptor agonists and antagonists","volume":"272","author":"Mukherjee R.","year":"1997","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_6_210_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0034"},{"key":"e_1_2_6_211_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164112444640"},{"key":"e_1_2_6_212_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/728461"},{"key":"e_1_2_6_213_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00419.2014"},{"key":"e_1_2_6_214_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb0908-893"},{"key":"e_1_2_6_215_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.1108"},{"key":"e_1_2_6_216_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.crd.0000102419.52594.90"},{"key":"e_1_2_6_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00144-1"},{"key":"e_1_2_6_218_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072761"},{"key":"e_1_2_6_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2012.12.003"},{"key":"e_1_2_6_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2012.12.003"},{"key":"e_1_2_6_221_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403866200"},{"key":"e_1_2_6_222_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9995"},{"key":"e_1_2_6_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2013.03.006"},{"key":"e_1_2_6_224_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.50.4484"},{"key":"e_1_2_6_225_1","doi-asserted-by":"publisher","DOI":"10.1007\/s000180050043"},{"key":"e_1_2_6_226_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203239"},{"key":"e_1_2_6_227_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0270-3"},{"key":"e_1_2_6_228_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0296-113"},{"key":"e_1_2_6_229_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03988"},{"key":"e_1_2_6_230_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-20"},{"key":"e_1_2_6_231_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3287"},{"key":"e_1_2_6_232_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119715"},{"key":"e_1_2_6_233_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj062"},{"key":"e_1_2_6_234_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.04.003"},{"key":"e_1_2_6_235_1","doi-asserted-by":"publisher","DOI":"10.1002\/msj.20157"},{"key":"e_1_2_6_236_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-005-0678-9"},{"key":"e_1_2_6_237_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02583"},{"key":"e_1_2_6_238_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150405"},{"key":"e_1_2_6_239_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1136-9"},{"key":"e_1_2_6_240_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/641087"},{"key":"e_1_2_6_241_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.078311"},{"key":"e_1_2_6_242_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12144"},{"key":"e_1_2_6_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81410-5"},{"key":"e_1_2_6_244_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00204"},{"key":"e_1_2_6_245_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.588"},{"key":"e_1_2_6_246_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.3.1854"},{"key":"e_1_2_6_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2004.12.013"},{"key":"e_1_2_6_248_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb18646.x"},{"key":"e_1_2_6_249_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00623-07"},{"key":"e_1_2_6_250_1","first-page":"103","article-title":"Hepatic microbody proliferation and catalase synthesis induced by methyl clofenapate, a hypilipidemic analog of CPIB","volume":"75","author":"Reddy J. K.","year":"1974","journal-title":"American Journal of Pathology"},{"key":"e_1_2_6_251_1","doi-asserted-by":"publisher","DOI":"10.1038\/283397a0"},{"key":"e_1_2_6_252_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.61.2.344"},{"key":"e_1_2_6_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2007.12.002"},{"key":"e_1_2_6_254_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.6.1747"},{"key":"e_1_2_6_255_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.21.1.193"},{"key":"e_1_2_6_256_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.66.5.733"},{"key":"e_1_2_6_257_1","doi-asserted-by":"publisher","DOI":"10.1038\/34178"},{"key":"e_1_2_6_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2014.07.004"},{"key":"e_1_2_6_259_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2006.03.012"},{"key":"e_1_2_6_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(07)82012-5"},{"key":"e_1_2_6_261_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2007.10.001"},{"key":"e_1_2_6_262_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80211-7"},{"key":"e_1_2_6_263_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-05426-0_1"},{"key":"e_1_2_6_264_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.06.023"},{"key":"e_1_2_6_265_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10596"},{"key":"e_1_2_6_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.05.022"},{"key":"e_1_2_6_267_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2007.02.003"},{"key":"e_1_2_6_268_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470015902.a0006145.pub3"},{"key":"e_1_2_6_269_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22423"},{"key":"e_1_2_6_270_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.11.4651-4663.2004"},{"key":"e_1_2_6_271_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.57.102904.190024"},{"key":"e_1_2_6_272_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505160200"},{"key":"e_1_2_6_273_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-30-09796.2003"},{"key":"e_1_2_6_274_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.06.050"},{"key":"e_1_2_6_275_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806142"},{"key":"e_1_2_6_276_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000260698.46517.8f"},{"key":"e_1_2_6_277_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06657.x"},{"key":"e_1_2_6_278_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.02.032"},{"key":"e_1_2_6_279_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/373560"},{"key":"e_1_2_6_280_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.33.19269"},{"key":"e_1_2_6_281_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.05.050"},{"key":"e_1_2_6_282_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.10.057"},{"key":"e_1_2_6_283_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.741"},{"key":"e_1_2_6_284_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006189"},{"key":"e_1_2_6_285_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20998"},{"key":"e_1_2_6_286_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-013-8272-8"},{"key":"e_1_2_6_287_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.10.8828512"},{"key":"e_1_2_6_288_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1268"},{"key":"e_1_2_6_289_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867033368295"},{"key":"e_1_2_6_290_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005777"},{"key":"e_1_2_6_291_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351419"},{"key":"e_1_2_6_292_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000214999.12921.4f"},{"key":"e_1_2_6_293_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.010"},{"key":"e_1_2_6_294_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.10.1189"},{"key":"e_1_2_6_295_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1403.002"},{"key":"e_1_2_6_296_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.05.019"},{"key":"e_1_2_6_297_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.652008"},{"key":"e_1_2_6_298_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/538141"},{"key":"e_1_2_6_299_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.237628.114"},{"key":"e_1_2_6_300_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2004.12.015"},{"key":"e_1_2_6_301_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.06.012"},{"key":"e_1_2_6_302_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.022"},{"key":"e_1_2_6_303_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.12.003"},{"key":"e_1_2_6_304_1","unstructured":"Takizawa T. Murakami K. Yano W. Abe K. Mizoguchi T. Yamazaki H. Asasuma A. Tanabe S. Hennuyer N. Staels B.&Fruchart J. C.(2012). K\u2010877 a highly potent and selective PPARa agonist improves dyslipidemia and atherosclerosis in experimental animal models. InThe 80th EAS Congress. Milan Italy May 2012."},{"key":"e_1_2_6_305_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000263217.36439.da"},{"key":"e_1_2_6_306_1","doi-asserted-by":"publisher","DOI":"10.2741\/2713"},{"key":"e_1_2_6_307_1","doi-asserted-by":"publisher","DOI":"10.1159\/000109936"},{"key":"e_1_2_6_308_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.11.058"},{"key":"e_1_2_6_309_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(97)00087-3"},{"key":"e_1_2_6_310_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-11-140"},{"key":"e_1_2_6_311_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90203-1"},{"key":"e_1_2_6_312_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-4900(00)01077-7"},{"key":"e_1_2_6_313_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.47.31108"},{"key":"e_1_2_6_314_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0862-13.2014"},{"key":"e_1_2_6_315_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/250126"},{"key":"e_1_2_6_316_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00332.x"},{"key":"e_1_2_6_317_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-5521(95)90045-4"},{"key":"e_1_2_6_318_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4861-4_19"},{"key":"e_1_2_6_319_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007894200"},{"key":"e_1_2_6_320_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.03.016"},{"key":"e_1_2_6_321_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.018911"},{"key":"e_1_2_6_322_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200317010-00003"},{"key":"e_1_2_6_323_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200003)47:3<286::AID-ANA3>3.0.CO;2-B"},{"key":"e_1_2_6_324_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0083-6729(06)74020-1"},{"key":"e_1_2_6_325_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3013"},{"key":"e_1_2_6_326_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.13656"},{"key":"e_1_2_6_327_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm990554g"},{"key":"e_1_2_6_328_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161207780858429"},{"key":"e_1_2_6_329_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021384"},{"key":"e_1_2_6_330_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80611-X"},{"key":"e_1_2_6_331_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb0196-87"},{"key":"e_1_2_6_332_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-1445"},{"key":"e_1_2_6_333_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80467-0"},{"key":"e_1_2_6_334_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3233\/JAD-130680","article-title":"Rosiglitazone prevents amyloid\u2010\u03b2 oligomer\u2010induced impairment of synapse formation and plasticity via increasing dendrite and spine mitochondrial number","volume":"39","author":"Xu S.","year":"2014","journal-title":"Journal of Alzheimer's Disease"},{"key":"e_1_2_6_335_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8882-7"},{"key":"e_1_2_6_336_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1569-12.2012"},{"key":"e_1_2_6_337_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.7.4541"},{"key":"e_1_2_6_338_1","doi-asserted-by":"publisher","DOI":"10.2174\/157489012799362359"},{"key":"e_1_2_6_339_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2007.04.021"},{"key":"e_1_2_6_340_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI27883"},{"key":"e_1_2_6_341_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.50.31771"},{"key":"e_1_2_6_342_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1165-14.2014"},{"key":"e_1_2_6_343_1","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/32696"},{"key":"e_1_2_6_344_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2013.03.024"},{"key":"e_1_2_6_345_1","doi-asserted-by":"crossref","first-page":"26817","DOI":"10.1016\/S0021-9258(19)74184-2","article-title":"Cloning of a new member of the peroxisome proliferator\u2010activated receptor gene family from mouse liver","volume":"268","author":"Zhu Y.","year":"1993","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_6_346_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3114"},{"key":"e_1_2_6_347_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00176"},{"key":"e_1_2_6_348_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-013-8435-5"},{"key":"e_1_2_6_349_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064019"},{"key":"e_1_2_6_350_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2011.07527.x"}],"container-title":["Biological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbrv.12320","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/brv.12320","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T02:58:08Z","timestamp":1696042688000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/brv.12320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,20]]},"references-count":349,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/brv.12320"],"URL":"https:\/\/doi.org\/10.1111\/brv.12320","archive":["Portico"],"relation":{},"ISSN":["1464-7931","1469-185X"],"issn-type":[{"value":"1464-7931","type":"print"},{"value":"1469-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,20]]},"assertion":[{"value":"2016-08-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}