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Our understanding of human PMPs remains limited, despite findings documenting their existence and association with human disease glycobiology. This review comprehensively surveys the structures, biosynthetic routes and functions of PMPs across the eukaryotic kingdoms with the aim of synthesising an improved understanding on the role of protein paucimannosylation in human health and diseases. Convincing biochemical, glycoanalytical and biological data detail a vast structural heterogeneity and fascinating tissue\u2010 and subcellular\u2010specific expression of PMPs within invertebrates and plants, often comprising multi\u2010\u03b11,3\/6\u2010fucosylation and \u03b21,2\u2010xylosylation amongst other glycan modifications and non\u2010glycan substitutions e.g. <jats:italic>O<\/jats:italic>\u2010methylation. Vertebrates and protists express less\u2010heterogeneous PMPs typically only comprising variable core fucosylation of bi\u2010 and trimannosylchitobiose core glycans. In particular, the Man\u03b11,6Man\u03b21,4GlcNAc(\u03b11,6Fuc)\u03b21,4GlcNAc\u03b2Asn glycan (M2F) decorates various human neutrophil proteins reportedly displaying bioactivity and structural integrity demonstrating that they are not degradation products. Less\u2010truncated paucimannosidic glycans (e.g. M3F) are characteristic glycosylation features of proteins expressed by human cancer and stem cells. Concertedly, these observations suggest the involvement of human PMPs in processes related to innate immunity, tumorigenesis and cellular differentiation. The absence of human PMPs in diverse bodily fluids studied under many (patho)physiological conditions suggests extravascular residence and points to localised functions of PMPs in peripheral tissues. Absence of PMPs in Fungi indicates that paucimannosylation is common, but not universally conserved, in eukaryotes. Relative to human PMPs, the expression of PMPs in plants, invertebrates and protists is more tissue\u2010wide and constitutive yet, similar to their human counterparts, PMP expression remains regulated by the physiology of the producing organism and PMPs evidently serve essential functions in development, cell\u2013cell communication and host\u2013pathogen\/symbiont interactions. In most PMP\u2010producing organisms, including humans, the <jats:italic>N<\/jats:italic>\u2010acetyl\u2010\u03b2\u2010hexosaminidase isoenzymes and linkage\u2010specific \u03b1\u2010mannosidases are glycoside hydrolases critical for generating PMPs <jats:italic>via N<\/jats:italic>\u2010acetylglucosaminyltransferase I (GnT\u2010I)\u2010dependent and GnT\u2010I\u2010independent truncation pathways. However, the identity and structure of many species\u2010specific PMPs in eukaryotes, their biosynthetic routes, strong tissue\u2010 and development\u2010specific expression, and diverse functions are still elusive. Deep exploration of these PMP features involving, for example, the characterisation of endogenous PMP\u2010recognising lectins across a variety of healthy and <jats:italic>N<\/jats:italic>\u2010acetyl\u2010\u03b2\u2010hexosaminidase\u2010deficient human tissue types and identification of microbial adhesins reactive to human PMPs, are amongst the many tasks required for enhanced insight into the glycobiology of human PMPs. In conclusion, the literature supports the notion that PMPs are significant, yet still heavily under\u2010studied biomolecules in human glycobiology that serve essential functions and create structural heterogeneity not dissimilar to other human <jats:italic>N<\/jats:italic>\u2010glycoprotein types. Human PMPs should therefore be recognised as bioactive glycoproteins that are distinctly different from the canonical <jats:italic>N<\/jats:italic>\u2010glycoprotein classes and which warrant a more dedicated focus in glycobiological research.<\/jats:p>","DOI":"10.1111\/brv.12548","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T07:45:52Z","timestamp":1565768752000},"page":"2068-2100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Human protein paucimannosylation: cues from the eukaryotic kingdoms"],"prefix":"10.1111","volume":"94","author":[{"given":"Harry C.","family":"Tjondro","sequence":"first","affiliation":[{"name":"Department of Molecular Sciences Macquarie University  Sydney New South Wales 2109 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