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The role of these crystallites in the pathogenesis and progression of osteoarthritis is controversial; it remains unclear whether they act as a disease initiator or are present as a result of joint damage. Recent studies reported that the molecular mechanisms regulating physiological calcification of skeletal tissues are similar to those regulating pathological or ectopic calcification of soft tissues. Pathological calcification takes place when the equilibrium is disrupted. Calcium phosphate crystallites are identified in most affected joints and the presence of these crystallites is closely correlated with the extent of joint destruction. These observations suggest that pathological calcification is most likely to be a disease initiator instead of an outcome of osteoarthritis progression. Inhibiting pathological crystallite deposition within joint tissues therefore represents a potential therapeutic target in the management of osteoarthritis.<\/jats:p>","DOI":"10.1111\/brv.12595","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T05:38:55Z","timestamp":1585028335000},"page":"960-985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Pathological calcification in osteoarthritis: an outcome or a disease initiator?"],"prefix":"10.1111","volume":"95","author":[{"given":"Jian\u2010fei","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Oral Mucosal Diseases, State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi Key Laboratory of Stomatology, School of Stomatology The Fourth Military Medical University 145 changle xi road, Xi'an Shaanxi 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010pin","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Oral Mucosal Diseases, State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi Key Laboratory of Stomatology, School of Stomatology The Fourth Military Medical University 145 changle xi road, Xi'an Shaanxi 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo\u2010cheng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Oral Mucosal Diseases, State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi Key Laboratory of Stomatology, School of Stomatology The Fourth Military Medical University 145 changle xi road, Xi'an Shaanxi 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian\u2010qian","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Oral Mucosal Diseases, State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi Key Laboratory of Stomatology, School of Stomatology The Fourth Military Medical University 145 changle xi road, Xi'an Shaanxi 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin R.","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Oral Mucosal Diseases, State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi Key Laboratory of Stomatology, School of Stomatology The Fourth Military Medical University 145 changle xi road, Xi'an Shaanxi 710032 China"},{"name":"Department of Endodontics, College of Graduate Studies Augusta University 1430, John Wesley Gilbert Drive, Augusta GA 30912 U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6653-0819","authenticated-orcid":false,"given":"Li\u2010na","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Oral Mucosal Diseases, State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi Key Laboratory of Stomatology, School of Stomatology The Fourth Military Medical University 145 changle xi road, Xi'an Shaanxi 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Oral Mucosal Diseases, State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi Key Laboratory of Stomatology, School of Stomatology The Fourth Military Medical University 145 changle xi road, Xi'an Shaanxi 710032 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.182"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0193"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-004-0767-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-016-2305-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/03008200009005638"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.42.Suppl_1.45"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.41.1.59"},{"key":"e_1_2_7_9_1","first-page":"266","article-title":"Molecular biology of matrix vesicles","volume":"314","author":"Anderson H. 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