{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:19:24Z","timestamp":1791980364138,"version":"4.4.0"},"reference-count":370,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["AIRC; IG\u201023670"],"award-info":[{"award-number":["AIRC; IG\u201023670"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008385","name":"Fondazione per la Ricerca sulla Fibrosi Cistica","doi-asserted-by":"publisher","award":["FFC #20\/2015"],"award-info":[{"award-number":["FFC #20\/2015"]}],"id":[{"id":"10.13039\/501100008385","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biological Reviews"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this review, we summarize current knowledge of perhaps one of the most intriguing phenomena in cell biology: the mitochondrial permeability transition pore (mPTP). This phenomenon, which was initially observed as a sudden loss of inner mitochondrial membrane impermeability caused by excessive calcium, has been studied for almost 50\u2009years, and still no definitive answer has been provided regarding its mechanisms. From its initial consideration as an\n                    <jats:italic>in vitro<\/jats:italic>\n                    artifact to the current notion that the mPTP is a phenomenon with physiological and pathological implications, a long road has been travelled. We here summarize the role of mitochondria in cytosolic calcium control and the evolving concepts regarding the mitochondrial permeability transition (mPT) and the mPTP. We show how the evolving mPTP models and mechanisms, which involve many proposed mitochondrial protein components, have arisen from methodological advances and more complex biological models. We describe how scientific progress and methodological advances have allowed milestone discoveries on mPTP regulation and composition and its recognition as a valid target for drug development and a critical component of mitochondrial biology.\n                  <\/jats:p>","DOI":"10.1111\/brv.12764","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T02:38:00Z","timestamp":1624329480000},"page":"2489-2521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":149,"title":["The mitochondrial permeability transition pore: an evolving concept critical for cell life and death"],"prefix":"10.1111","volume":"96","author":[{"given":"Giampaolo","family":"Morciano","sequence":"first","affiliation":[{"name":"Maria Cecilia Hospital, GVM Care &amp; Research  Via Corriera 1 Cotignola Ravenna 48033 Italy"},{"name":"Department of Medical Sciences, Section of Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA) University of Ferrara  Via Fossato di Mortara 70 Ferrara 44121 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Naumova","sequence":"additional","affiliation":[{"name":"Department of Cardiac Thoracic and Vascular Sciences and Public Health University of Padua Medical School  Via Giustiniani 2 Padova 35128 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Koprowski","sequence":"additional","affiliation":[{"name":"Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology Polish Academy of Sciences  3 Pasteur Street Warsaw 02\u2010093 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Valente","sequence":"additional","affiliation":[{"name":"CNC \u2010 Center for Neuroscience and Cell Biology, CIBB \u2010 Centre for Innovative Biomedicine and Biotechnology University of Coimbra  UC Biotech, Biocant Park Cantanhede 3060\u2010197 Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7014-4614","authenticated-orcid":false,"given":"Vilma A.","family":"Sard\u00e3o","sequence":"additional","affiliation":[{"name":"CNC \u2010 Center for Neuroscience and Cell Biology, CIBB \u2010 Centre for Innovative Biomedicine and Biotechnology University of Coimbra  UC Biotech, Biocant Park Cantanhede 3060\u2010197 Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaiza","family":"Potes","sequence":"additional","affiliation":[{"name":"Laboratory of Mitochondrial Biology and Metabolism, Nencki Institute of Experimental Biology Polish Academy of Sciences  3 Pasteur Street Warsaw 02\u2010093 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Rimessi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Section of Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA) University of Ferrara  Via Fossato di Mortara 70 Ferrara 44121 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0789-4521","authenticated-orcid":false,"given":"Mariusz R.","family":"Wieckowski","sequence":"additional","affiliation":[{"name":"Laboratory of Mitochondrial Biology and Metabolism, Nencki Institute of Experimental Biology Polish Academy of Sciences  3 Pasteur Street Warsaw 02\u2010093 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo J.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"CNC \u2010 Center for Neuroscience and Cell Biology, CIBB \u2010 Centre for Innovative Biomedicine and Biotechnology University of Coimbra  UC Biotech, Biocant Park Cantanhede 3060\u2010197 Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.86434"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(80)90723-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1401591111"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210600"},{"issue":"6","key":"e_1_2_11_6_1","first-page":"H1699","article-title":"Cyclosporin inhibits mitochondrial calcium efflux in isolated adult rat ventricular cardiomyocytes","volume":"262","author":"Altschuld R. 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