{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:43:14Z","timestamp":1792633394863,"version":"4.5.0"},"reference-count":273,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T00:00:00Z","timestamp":1652572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470577"],"award-info":[{"award-number":["81470577"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270956"],"award-info":[{"award-number":["81270956"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biological Reviews"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Atherosclerosis, characterized by lipid\u2010rich plaques in the arterial wall, is an age\u2010related disorder and a leading cause of mortality worldwide. However, the specific mechanisms remain complex. Recently, emerging evidence has demonstrated that senescence of various types of cells, such as endothelial cells (\n                    <jats:styled-content style=\"fixed-case\">ECs<\/jats:styled-content>\n                    ), vascular smooth muscle cells (\n                    <jats:styled-content style=\"fixed-case\">VSMCs<\/jats:styled-content>\n                    ), macrophages, endothelial progenitor cells (\n                    <jats:styled-content style=\"fixed-case\">EPCs<\/jats:styled-content>\n                    ), and adipose\u2010derived mesenchymal stem cells (\n                    <jats:styled-content style=\"fixed-case\">AMSCs<\/jats:styled-content>\n                    ) contributes to atherosclerosis. Cellular senescence and atherosclerosis share various causative stimuli, in which dyslipidemia has attracted much attention. Dyslipidemia, mainly referred to elevated plasma levels of atherogenic lipids or lipoproteins, or functional impairment of anti\u2010atherogenic lipids or lipoproteins, plays a pivotal role both in cellular senescence and atherosclerosis. In this review, we summarize the current evidence for dyslipidemia\u2010induced cellular senescence during atherosclerosis, with a focus on low\u2010density lipoprotein (\n                    <jats:styled-content style=\"fixed-case\">LDL<\/jats:styled-content>\n                    ) and its modifications, hydrolysate of triglyceride\u2010rich lipoproteins (\n                    <jats:styled-content style=\"fixed-case\">TRLs<\/jats:styled-content>\n                    ), and high\u2010density lipoprotein (\n                    <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\n                    ), respectively. Furthermore, we describe the underlying mechanisms linking dyslipidemia\u2010induced cellular senescence and atherosclerosis. Finally, we discuss the senescence\u2010related therapeutic strategies for atherosclerosis, with special attention given to the anti\u2010atherosclerotic effects of promising geroprotectors as well as anti\u2010senescence effects of current lipid\u2010lowering drugs.\n                  <\/jats:p>","DOI":"10.1111\/brv.12866","type":"journal-article","created":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T19:35:01Z","timestamp":1652643301000},"page":"1844-1867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":149,"title":["New insight into dyslipidemia\u2010induced cellular senescence in atherosclerosis"],"prefix":"10.1111","volume":"97","author":[{"given":"Qunyan","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Geriatrics, The Second Xiangya Hospital Central South University Changsha Hunan 410011 PR China"},{"name":"Institute of Aging and Age\u2010related Disease Research Central South University Changsha Hunan 410011 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Geriatric Cardiology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450000 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital Central South University Changsha Hunan 410011 PR China"},{"name":"Research Institute of Blood Lipid and Atherosclerosis Central South University Changsha Hunan 410011 PR China"},{"name":"Modern Cardiovascular Disease Clinical Technology Research Center of Hunan Province Changsha Hunan 410011 PR China"},{"name":"Cardiovascular Disease Research Center of Hunan Province Changsha Hunan 410011 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital Central South University Changsha Hunan 410011 PR China"},{"name":"Research Institute of Blood Lipid and Atherosclerosis Central South University Changsha Hunan 410011 PR China"},{"name":"Modern Cardiovascular Disease Clinical Technology Research Center of Hunan Province Changsha Hunan 410011 PR China"},{"name":"Cardiovascular Disease Research Center of Hunan Province Changsha Hunan 410011 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Xiangya Hospital Central South University Changsha Hunan 410011 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6979-701X","authenticated-orcid":false,"given":"Ling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital Central South University Changsha Hunan 410011 PR China"},{"name":"Research Institute of Blood Lipid and Atherosclerosis Central South University Changsha Hunan 410011 PR China"},{"name":"Modern Cardiovascular Disease Clinical Technology Research Center of Hunan Province Changsha Hunan 410011 PR China"},{"name":"Cardiovascular Disease Research Center of Hunan Province Changsha Hunan 410011 PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.210427"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M088245"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.302313"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht532"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx015"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa770"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy022"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.057"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12496"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000070067.64040.7C"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10600"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706628"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0227-9"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303887"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2021.102379"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.82.6.704"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn082"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv008"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103034"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2016.93"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz962"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2013.06.001"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0350454"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354235"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-018-9763-7"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2010.07.005"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308301"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1365-2"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040583"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20236093"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs352"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-173377"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.182998"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.185777"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf6659"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2014.04.007"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2017.01.009"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2840437"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010238"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90470.2008"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.03.004"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.10.2281"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.303804"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07260.x"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2016.05.013"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.06.066"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000043456.48735.20"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.12.045"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2003.08.016"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00689.2008"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.01.021"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.12.039"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.08.008"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2003.09.005"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001202"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.E598"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305896"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61682-2"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107765"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306301"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900241"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2014.01.015"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.2.372"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.06.004"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.124404"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvy007"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.318353"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.312732"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10688-x"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021317-121454"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030856"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.054346"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24581"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.217745"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.248617"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300063"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002761"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2004.04022.x"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000173310.85845.7b"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059344"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/175291"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172748"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00512"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.09.046"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068197"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.312498"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.01.018"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2008.02272.x"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.21.6.955"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000093278.75565.87"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06334.x"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-008-0742-z"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.313775"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000158380.44231.fe"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2020.24.1.69"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-019-00095-x"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.11.005"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.20"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.70.1076"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001693"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2015.1027779"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M067108"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.215392"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.05.006"},{"issue":"1","key":"e_1_2_10_106_1","first-page":"799","article-title":"Quercetin protects against oxLDLinduced injury via regulation of ABCAl, LXRalpha and PCSK9 in RAW264.7 macrophages","volume":"18","author":"Li S.","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00038.2018"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2017.09.012"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.08.011"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13282"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13853"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082379"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1159\/000485820"},{"issue":"4","key":"e_1_2_10_114_1","first-page":"5109","article-title":"Polysaccharide from Fuzi protects against OxLDLinduced calcification of human vascular smooth muscle cells by increasing autophagic activity","volume":"17","author":"Liao L.","year":"2018","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.009"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.03.109"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609581"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000074880.25540.D0"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.05.024"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2008.11.002"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.300543"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.10.053"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-016-0274-z"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20190966"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1287"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24849"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt171"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3018190"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M500507-JLR200"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01174.2006"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.182899"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-011-9305-6"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4343-y"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21702"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.181"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000233315.38086.bc"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14063"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.1975.tb05227.x"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.10.009"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.09.013"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000013836.85741.17"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000093274.82929.22"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2014"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2016.2633"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000137191.02577.86"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0378"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(00)00641-9"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181009"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00455.2009"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.03.026"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2019.0402"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.06.023"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.01.022"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.246876"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308537"},{"key":"e_1_2_10_157_1","doi-asserted-by":"crossref","first-page":"6487825","DOI":"10.1155\/2017\/6487825","article-title":"Long\u2010term treatment of native LDL induces senescence of cultured human endothelial cells","volume":"2017","author":"Oh S. T.","year":"2017","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.205914"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00391.x"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008758"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2018.1501132"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.210500"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf010576n"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12950"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12969"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.12.179"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2015-0165"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0067-7"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165983"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2019.06.007"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt044"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-5-17"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12461"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-018-0024-8"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.11.046"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2007.05.025"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-018-0777-x"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S207774"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12322"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.19800"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.113734"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45005-5"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000082924.75945.48"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707914"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1809798"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-171439"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12458"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.124"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9080858"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187934"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.08.003"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.054"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.504340"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010282"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.41.2.248"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12948-0"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01405.2006"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000775"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2018.09.005"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000117403.64398.53"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2017.04.006"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400559"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092777"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10833"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.11.029"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.041658"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.305874"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198904063201407"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz919"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.07.123"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2004.12.002"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000259299.38843.64"},{"key":"e_1_2_10_213_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205814200"},{"key":"e_1_2_10_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.08.022"},{"key":"e_1_2_10_215_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.RV17004"},{"key":"e_1_2_10_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.01.012"},{"key":"e_1_2_10_217_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M700305-JLR200"},{"key":"e_1_2_10_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.08.047"},{"key":"e_1_2_10_219_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00265.2004"},{"key":"e_1_2_10_220_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2010.00608.x"},{"key":"e_1_2_10_221_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000257912.78915.af"},{"key":"e_1_2_10_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.01.004"},{"key":"e_1_2_10_223_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000258023.76515.a3"},{"key":"e_1_2_10_224_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12423"},{"key":"e_1_2_10_225_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000216600.37436.cf"},{"key":"e_1_2_10_226_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315644"},{"key":"e_1_2_10_227_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt057"},{"key":"e_1_2_10_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2003.11.012"},{"key":"e_1_2_10_229_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh1301.093953"},{"key":"e_1_2_10_230_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0051com"},{"key":"e_1_2_10_231_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-13-104"},{"key":"e_1_2_10_232_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304029"},{"key":"e_1_2_10_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2007.09.006"},{"key":"e_1_2_10_234_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.210054"},{"key":"e_1_2_10_235_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01366.2007"},{"key":"e_1_2_10_236_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M700505-JLR200"},{"key":"e_1_2_10_237_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2013.1494"},{"key":"e_1_2_10_238_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016457"},{"key":"e_1_2_10_239_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20180283"},{"key":"e_1_2_10_240_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12792"},{"key":"e_1_2_10_241_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7151946"},{"key":"e_1_2_10_242_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303415"},{"key":"e_1_2_10_243_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000115557.25127.8D"},{"key":"e_1_2_10_244_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2538"},{"key":"e_1_2_10_245_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e318197c637"},{"key":"e_1_2_10_246_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202298"},{"key":"e_1_2_10_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.09.020"},{"key":"e_1_2_10_248_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0092-9"},{"key":"e_1_2_10_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2015.10.006"},{"key":"e_1_2_10_250_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.220749"},{"issue":"1","key":"e_1_2_10_251_1","first-page":"25","article-title":"Fisetin ameliorates atherosclerosis by regulating PCSK9 and LOX\u20101 in apoE\u2212\/\u2212 mice","volume":"21","author":"Yan L.","year":"2021","journal-title":"Experimental and Therapeutic Medicine"},{"key":"e_1_2_10_252_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2008.02.001"},{"key":"e_1_2_10_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2010.12.075"},{"key":"e_1_2_10_254_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2020.102265"},{"key":"e_1_2_10_255_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-017-0447-0"},{"key":"e_1_2_10_256_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13258-018-00777-4"},{"key":"e_1_2_10_257_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.11.002"},{"key":"e_1_2_10_258_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2020.0117"},{"key":"e_1_2_10_259_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002271"},{"key":"e_1_2_10_260_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003282"},{"key":"e_1_2_10_261_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn081"},{"key":"e_1_2_10_262_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.156554"},{"key":"e_1_2_10_263_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143814"},{"key":"e_1_2_10_264_1","doi-asserted-by":"publisher","DOI":"10.1159\/000447902"},{"key":"e_1_2_10_265_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf2693"},{"key":"e_1_2_10_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2017.03.009"},{"key":"e_1_2_10_267_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2017.12.001"},{"key":"e_1_2_10_268_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-018-3476-8"},{"key":"e_1_2_10_269_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-016-9504-y"},{"key":"e_1_2_10_270_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-10-210"},{"key":"e_1_2_10_271_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146777"},{"key":"e_1_2_10_272_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102710"},{"key":"e_1_2_10_273_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.09.033"},{"key":"e_1_2_10_274_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.215483"}],"container-title":["Biological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/brv.12866","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/brv.12866","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/brv.12866","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T18:10:49Z","timestamp":1727201449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/brv.12866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,15]]},"references-count":273,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/brv.12866"],"URL":"https:\/\/doi.org\/10.1111\/brv.12866","archive":["Portico"],"relation":{},"ISSN":["1464-7931","1469-185X"],"issn-type":[{"value":"1464-7931","type":"print"},{"value":"1469-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,15]]},"assertion":[{"value":"2021-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}