{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:51:07Z","timestamp":1790621467008,"version":"4.1.0"},"reference-count":109,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M712240"],"award-info":[{"award-number":["2022M712240"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82141130"],"award-info":[{"award-number":["82141130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["23NSFSC1519"],"award-info":[{"award-number":["23NSFSC1519"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biological Reviews"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cranial bones constitute a protective shield for the vulnerable brain tissue, bound together as a rigid entity by unique immovable joints known as sutures. Cranial sutures serve as major growth centres for calvarial morphogenesis and have been identified as a niche for mesenchymal stem cells (MSCs) and\/or skeletal stem cells (SSCs) in the craniofacial skeleton. Despite the established dogma of cranial bone and suture biology, technological advancements now allow us to investigate these tissues and structures at unprecedented resolution and embrace multiple novel biological insights. For instance, a decrease or imbalance of representation of SSCs within sutures might underlie craniosynostosis; dural sinuses enable neuroimmune crosstalk and are newly defined as immune hubs; skull bone marrow acts as a myeloid cell reservoir for the meninges and central nervous system (CNS) parenchyma in mediating immune surveillance, etc. In this review, we revisit a growing body of recent studies that explored cranial bone and suture biology using cutting\u2010edge techniques and have expanded our current understanding of this research field, especially from the perspective of development, homeostasis, injury repair, resident MSCs\/SSCs, immunosurveillance at the brain's border, and beyond.<\/jats:p>","DOI":"10.1111\/brv.12975","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T08:04:38Z","timestamp":1683878678000},"page":"1749-1767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dissecting calvarial bones and sutures at single\u2010cell resolution"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2820-9098","authenticated-orcid":false,"given":"Bo","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingya","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Fan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihe","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1446-0692","authenticated-orcid":false,"given":"Longjiang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan 610041 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Okano","sequence":"additional","affiliation":[{"name":"Department of Physiology Keio University School of Medicine  35 Shinanomachi, Shinjuku\u2010ku Tokyo 1608582 Japan"},{"name":"Laboratory for Marmoset Neural Architecture RIKEN Center for Brain Science  Wako\u2010shi Saitama 3510198 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4258-2152","authenticated-orcid":false,"given":"Takehito","family":"Ouchi","sequence":"additional","affiliation":[{"name":"Department of Physiology Tokyo Dental College  2\u20109\u201018 Kanda\u2010Misaki\u2010cho, Chiyoda\u2010ku Tokyo 1010061 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046672"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29675-w"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20142290"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4052"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3028"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.102210"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.03.002"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf9277"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03549-5"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090504"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.029"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.12.002"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00135"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.02.013"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.03.004"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.65694"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.11.010"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abf7844"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.09.022"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4042"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0554-8"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05844-8"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.06.009"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240600855905"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.08.008"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3666"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27594-w"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24917-9"},{"key":"e_1_2_11_30_1","first-page":"393","article-title":"The development of fibroblast colonies in monolayer cultures of Guinea\u2010pig bone marrow and spleen cells","volume":"3","author":"Friedenstein A. J.","year":"1970","journal-title":"Cell and Tissue Kinetics"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-196803000-00009"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.09.011"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0121-4"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2015.07.006"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3802"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-018-0031-x"},{"key":"e_1_2_11_37_1","first-page":"205","volume-title":"Handbook of Clinical Neurology","author":"Harrison R. A.","year":"2018"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0213-2"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107871"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27402-5"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01158-6"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ctdb.2015.07.004"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2001.0487"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26593-1"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4561"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-019-0201-x"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01066-w"},{"key":"e_1_2_11_48_1","article-title":"Multi\u2010omics and 3D\u2010imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammation","volume":"18","author":"Kolabas Z. I.","year":"2021","journal-title":"bioRxiv"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4610"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-022-01502-8"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.66078"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0070-2153(05)66009-7"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081129"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.021"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0227-9"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14432"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1726"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2021.08.002"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608501101"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10526"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000727"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb4416"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01029-1"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247651"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09262"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24801-6"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107696"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adc8810"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.01.040"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2022.05.001"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.11.003"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.11.013"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.34126"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.12.JNS101732"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01060-2"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26455-w"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.04.003"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.12.040"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2005.01.022"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00279-w"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021108605"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-021-00880-y"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.09.018"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aas9536"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110140"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2020.06.013"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2103087118"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-00318-y"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.07.006"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0393-4"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4573"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202003390"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-022-01051-9"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.09.016"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1093\/stcltm\/szac004"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.653579"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.03.002"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000003848"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.042"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26302-y"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0736-z"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl5716"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-017-0388-4"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.037"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb4776"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.348190.120"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105893"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3139"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515603972"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.009"}],"container-title":["Biological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/brv.12975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:39:55Z","timestamp":1693787995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/brv.12975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,12]]},"references-count":109,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/brv.12975"],"URL":"https:\/\/doi.org\/10.1111\/brv.12975","archive":["Portico"],"relation":{},"ISSN":["1464-7931","1469-185X"],"issn-type":[{"value":"1464-7931","type":"print"},{"value":"1469-185X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,12]]},"assertion":[{"value":"2023-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}