{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:10:34Z","timestamp":1792113034238,"version":"4.4.0"},"reference-count":94,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Adoles Ment Health"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anxiety\u2010based disorders are common and are often chronic with an onset during childhood or adolescence. An emerging literature has examined the role of inflammation in these disorders by measuring blood concentrations of inflammatory markers such as cytokines, C\u2010reactive protein (CRP) and immune markers such as white blood cell counts. However, existing results are inconsistent, with available meta\u2010analyses only including adult populations. We believe this is the first systematic review and meta\u2010analysis to investigate these inconsistencies among the population of children and adolescents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A systematic search of five electronic databases was conducted to identify studies which compared inflammatory markers between individuals with an anxiety\u2010based disorder and healthy controls. Study quality was assessed, and pooled effect sizes (Hedges\u2019\n                      <jats:italic>g<\/jats:italic>\n                      ) were calculated using random\u2010effects meta\u2010analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine independent studies were identified. The combined meta\u2010analysis of 16 cytokines and CRP was approaching significance; however, no significant between\u2010group difference was observed for meta\u2010analyses of individual inflammatory or immune markers. Heterogeneity was high, and quality assessments identified important limitations; primarily, small sample sizes and a lack of control over confounding variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although no significant effects were observed, the small number of included studies and limitations in study or reporting quality render these findings provisional. Research in this area has the potential for important clinical implications in relation to therapeutic interventions. Important recommendations for further research are put forth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/camh.12434","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T02:14:15Z","timestamp":1605579255000},"page":"143-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Review: Inflammation and anxiety\u2010based disorders in children and adolescents \u2013 a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3024-501X","authenticated-orcid":false,"given":"Chelsea","family":"Parsons","sequence":"first","affiliation":[{"name":"School of Psychology University of Adelaide Adelaide SA 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