{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T10:23:08Z","timestamp":1792578188337,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT\u2010191702"],"award-info":[{"award-number":["PJT\u2010191702"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["296785"],"award-info":[{"award-number":["296785"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Adoles Ment Health"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anorexia nervosa has the potential to affect fetal neurodevelopment. We examined the association between maternal anorexia nervosa and mental, substance\u2010related, and neurodevelopmental morbidity in offspring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of 1,269,370 children in Quebec, Canada, between 2006 and 2022. The main exposure was maternal anorexia nervosa requiring admission. The outcome was childhood hospitalization for mental, substance\u2010related, or neurodevelopmental disorders between birth and age 17\u2009years, with follow\u2010up ending in 2023. We estimated hazard ratios (HR) and 95% confidence intervals (CI) for the association between maternal anorexia nervosa and child outcomes using Cox regression models adjusted for patient characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 2,447 (0.2%) children had a mother admitted for anorexia nervosa. Children of mothers with anorexia nervosa had higher hospitalization rates for mental, substance\u2010related, and neurodevelopmental morbidity than other children (104.7 vs. 51.4 per 1,000 by age 17\u2009years). Children whose mothers had anorexia nervosa were particularly at risk of mental health hospitalization (HR 2.30, 95% CI 1.52\u20133.49), especially for anorexia nervosa (HR 10.62, 95% CI 5.06\u201322.29) and anxiety and stress disorders (HR 1.84, 95% CI 1.09\u20133.08), compared with unexposed children. Maternal anorexia nervosa was associated with substance\u2010related (HR 2.01, 95% CI 1.26\u20133.21) and neurodevelopmental morbidity in children (HR 1.55, 95% CI 1.19\u20132.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Maternal anorexia nervosa is associated with childhood hospitalization for mental health, substance\u2010related, and neurodevelopmental morbidity, although results should be interpreted with caution owing to potential confounders. Mothers with anorexia nervosa may benefit from psychosocial support to prevent mental and neurodevelopmental morbidity in offspring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/camh.70051","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T12:15:15Z","timestamp":1764677715000},"page":"125-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Maternal anorexia nervosa and risk of mental and neurodevelopmental morbidity in offspring"],"prefix":"10.1111","volume":"31","author":[{"given":"Sam","family":"Amar","sequence":"first","affiliation":[{"name":"Faculty of Medicine, McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"C\u00f4t\u00e9\u2010Corriveau","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sainte\u2010Justine University Hospital Centre University of Montreal  Montreal QC Canada"},{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimi","family":"Isra\u00ebl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Steiger","sequence":"additional","affiliation":[{"name":"Department of Psychiatry McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Low","sequence":"additional","affiliation":[{"name":"Department of Psychiatry McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Chadi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sainte\u2010Justine University Hospital Centre University of Montreal  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9milie","family":"Brousseau","sequence":"additional","affiliation":[{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec  Montreal QC Canada"},{"name":"University of Montreal Hospital Research Centre  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahantara","family":"Lafleur","sequence":"additional","affiliation":[{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec  Montreal QC Canada"},{"name":"University of Montreal Hospital Research Centre  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2412-0459","authenticated-orcid":false,"given":"Nathalie","family":"Auger","sequence":"additional","affiliation":[{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec  Montreal QC Canada"},{"name":"University of Montreal Hospital Research Centre  Montreal QC Canada"},{"name":"Department of Social and Preventive Medicine, School of Public Health University of Montreal  Montreal Quebec Canada"},{"name":"Department of Epidemiology, Biostatistics and Occupational Health McGill University  Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23251"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03354427"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.12736"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12389"},{"key":"e_1_2_12_6_1","volume-title":"International Statistical Classification of Diseases and Related Health Problems, tenth revision, Canada (ICD\u201010\u2010CA)\u2014Alphabetical Index and Tabular List","author":"Canadian Institute for Health Information","year":"2022"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2010.06.002"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10578-014-0462-6"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/erv.2218"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103530"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40337-021-00516-3"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-108X(199507)18:1<39::AID-EAT2260180105>3.0.CO;2-I"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(22)00031-1"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11040792"},{"key":"e_1_2_12_15_1","unstructured":"Institut de la statistique du Qu\u00e9bec. 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