{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:55:16Z","timestamp":1790564116061,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["acamh.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Child Adoles Ment Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The core affect (CA) hypothesis posits that exercise serves either to increase positive affect or reduce negative affect. One rarely examined implication of the CA hypothesis is that multiple short exercise bouts distributed throughout the week, rather than one long training bout, would lead to better outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010four university students with depression were randomly allocated to one of three groups: (1) a control group participating in weekly health education sessions, (2) a low\u2010frequency exercise training (LFET) group running once weekly for 60\u2009min, and (3) a high\u2010frequency exercise training (HFET) group running four times weekly for 15\u2009min. All interventions lasted 3\u2009weeks without interruption. Depressive symptoms were assessed pre\u2010 and postintervention using the PHQ\u20109 questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the control group, depressive symptoms were significantly reduced in the HFET group (Hedges's\n                      <jats:italic>g<\/jats:italic>\n                      \u2009=\u2009\u22120.89, 95% CI [\u22121.57, \u22120.20]), but not in the LFET group (Hedges's\n                      <jats:italic>g<\/jats:italic>\n                      \u2009=\u2009\u22120.34, 95% CI [\u22120.99, 0.32]). Moreover, the proportion of participants achieving clinically significant improvement (CSI) was more than threefold higher in the HFET group (38.9%) than in the control group (11.1%),\n                      <jats:italic>z<\/jats:italic>\n                      \u2009=\u20091.93,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.027, and almost double that of the LFET group (22.2%). Finally, participants in the HFET group, but not in the LFET group, reported significantly higher remission rates than controls (55.6% vs. 27.8%,\n                      <jats:italic>z<\/jats:italic>\n                      \u2009=\u20091.69,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.046).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although these findings support the CA hypothesis, they should be interpreted cautiously because of the small sample size and short intervention period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/camh.70134","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:10:22Z","timestamp":1790561422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High\u2010 versus low\u2010frequency exercise for depression in university students: a single\u2010blind randomized controlled trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6205-3242","authenticated-orcid":false,"given":"Fabien D.","family":"Legrand","sequence":"first","affiliation":[{"name":"Laboratoire PSMS (UR7507) UFR STAPS, Universit\u00e9 de Reims Champagne\u2010Ardenne  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Duberg","sequence":"additional","affiliation":[{"name":"University Health Care Research Center, Faculty of Medicine and Health \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"crossref","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders \u2013 DSM 5","author":"American Psychiatric Association","year":"2013"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2021.105336"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2023.110931"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.v06n0301"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/1938492"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/11590680-000000000-00000"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318213fefb"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2026.121618"},{"key":"e_1_2_13_11_1","unstructured":"Haute Autorit\u00e9 de Sant\u00e9. (2022).D\u00e9pression: prescription d'activit\u00e9 physique [Depression: physical activity prescription]. Retrieved September 25 2026 from:https:\/\/www.has\u2010sante.fr\/upload\/docs\/application\/pdf\/2022\u201008\/synthese_aps_depression_vf.pdf"},{"key":"e_1_2_13_12_1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jad.2020.11.066","article-title":"Meaningful change in depression symptoms assessed with the patient health questionnaire (PHQ\u20109) and Montgomery\u2010\u00c5sberg depression rating scale (MADRS) among patients with treatment resistant depression in two, randomized, double\u2010blind, active\u2010controlled trials of Esketamine nasal spray combined with a new oral antidepressant","volume":"281","author":"Hudgens C.","year":"2021","journal-title":"Journal of Affective Disorders"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.09.040"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2006.030130"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.09.043"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.11.047"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2024.03.074"},{"key":"e_1_2_13_19_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpsychores.2025.112375","article-title":"Feasibility of using a clinical measure of depression severity to assess treatment impact on total cost of care","volume":"197","author":"Maeng D.","year":"2025","journal-title":"Journal of Psychosomatic Research"},{"key":"e_1_2_13_20_1","doi-asserted-by":"crossref","first-page":"E191E1\u20106","DOI":"10.1503\/cmaj.110829","article-title":"Optimal cut\u2010off score for diagnosing depression with the patient health questionnaire (PHQ\u20109): A meta\u2010analysis","volume":"184","author":"Manea L.","year":"2012","journal-title":"Canadian Medical Association Journal"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2033475"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-075847"},{"key":"e_1_2_13_23_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2024"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mhpa.2015.10.001"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2023.101117"},{"key":"e_1_2_13_26_1","first-page":"1242","article-title":"Accuracy of commonly used age\u2010predicted maximal heart rate equations","volume":"13","author":"Shookster D.","year":"2020","journal-title":"International Journal of Exercise Science"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-095069"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.10.019"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13034-022-00453-2"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.10.019"}],"container-title":["Child and Adolescent Mental Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/camh.70134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/camh.70134","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/camh.70134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:10:25Z","timestamp":1790561425000},"score":1,"resource":{"primary":{"URL":"https:\/\/acamh.onlinelibrary.wiley.com\/doi\/10.1111\/camh.70134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":29,"alternative-id":["10.1111\/camh.70134"],"URL":"https:\/\/doi.org\/10.1111\/camh.70134","archive":["Portico"],"relation":{},"ISSN":["1475-357X","1475-3588"],"issn-type":[{"value":"1475-357X","type":"print"},{"value":"1475-3588","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]},"assertion":[{"value":"2026-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"camh.70134"}}