{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:56:23Z","timestamp":1778770583464,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,20]],"date-time":"2013-01-20T00:00:00Z","timestamp":1358640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>Circulating adiponectin levels are inversely associated with risk of various obesity\u2010related cancers. However, the effect of adiponectin on carcinogenesis and progression of tongue squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content>) remains unknown. We measured serum adiponectin levels in 59 patients with <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> and 50 healthy controls. Expression of adiponectin and its receptors in paired tumor and paracancerous specimens were determined by immunohistochemical staining (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>37) and western blot (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>30), respectively. Serum adiponectin level was lower in patients than in controls (5.0\u00a0\u00b1\u00a02.4 <jats:italic>vs<\/jats:italic> 8.4\u00a0\u00b1\u00a03.5\u00a0\u03bcg\/mL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), and was inversely associated with histological grade and lymph node metastasis but not tumor size. Local adiponectin levels in tumor tissue gradually decreased as tumor\u2010node\u2010metastasis stage increased, while the expression of adiponectin receptors was unchanged. In addition, serum adiponectin levels in the <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content> patients without metabolic and cardiovascular diseases, or without smoking and drinking habits, were still lower than in controls. Furthermore, adiponectin inhibited the migration, but not proliferation, of <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>15 cells <jats:italic>in\u00a0vitro<\/jats:italic>. These results indicate that a decreased adiponectin level is associated with risk of <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content>. Hypoadiponectinemia might be used as a biomarker to predict an aggressive phenotype of <jats:styled-content style=\"fixed-case\">TSCC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cas.12077","type":"journal-article","created":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T04:48:09Z","timestamp":1353991689000},"page":"206-213","source":"Crossref","is-referenced-by-count":20,"title":["Decreased adiponectin level is associated with aggressive phenotype of tongue squamous cell carcinoma"],"prefix":"10.1111","volume":"104","author":[{"given":"Xiao\u2010Hong","family":"Guo","sequence":"first","affiliation":[{"name":"Center for Salivary Gland Diseases of Peking University School and Hospital of Stomatology, Department of Physiology and Pathophysiology Peking University Health Science Center and Key Laboratory of Molecular Cardiovascular Sciences Beijing 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