{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:34:00Z","timestamp":1791401640912,"version":"4.3.3"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,10]],"date-time":"2013-03-10T00:00:00Z","timestamp":1362873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p>We report an adult <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell leukemia\/lymphoma patient suffering from <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tevens\u2013<jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>ohnson <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>yndrome (<jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>) during mogamulizumab (humanized anti\u2010<jats:styled-content style=\"fixed-case\">CCR<\/jats:styled-content>4 monoclonal antibody) treatment. There was a durable significant reduction of the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup><jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>25<jats:sup>high<\/jats:sup><jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>3<jats:sup>+<\/jats:sup> regulatory <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg) cell subset in the patient's <jats:styled-content style=\"fixed-case\">PBMC<\/jats:styled-content>, and the affected inflamed skin almost completely lacked <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>3\u2010positive cells. This implies an association between reduction of the <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg subset by mogamulizimab and occurrence of <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>. The present case should contribute not only to our understanding of human pathology resulting from therapeutic depletion of <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>reg cells, but also alert us to the possibility of immune\u2010related severe adverse events such as <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content> when using mogamulizumab. We are currently conducting a clinical trial of mogamulizumab for CCR4\u2010negative solid cancers (UMIN000010050), specifically aiming to deplete Treg cells.<\/jats:p>","DOI":"10.1111\/cas.12116","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T10:37:11Z","timestamp":1359542231000},"page":"647-650","source":"Crossref","is-referenced-by-count":120,"title":["Stevens\u2013Johnson <scp>S<\/scp>yndrome associated with mogamulizumab treatment of adult <scp>T<\/scp>\u2010cell leukemia\u00a0\/\u00a0lymphoma"],"prefix":"10.1111","volume":"104","author":[{"given":"Takashi","family":"Ishida","sequence":"first","affiliation":[{"name":"Department of Medical Oncology and Immunology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asahi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Immunology Nagoya City University Graduate 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