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Although many efforts, such as high\u2010intensity, short\u2010duration combination chemotherapy, have been devoted to improving therapy for this rapidly proliferating neoplasm, there are still significant treatment\u2010associated toxicities. Therefore, there remains a need for novel effective therapeutic strategies. Micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s play a role in \u201cfine tuning\u201d the physiological and pathological differentiation process, by which cells can rapidly regulate dynamic events such as cell\u2010lineage decisions and morphogenesis. This unique mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> feature shifts the traditional one drug target paradigm to a novel one drug multiple targets paradigm. Here, we found that <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> cell lines showed an extremely low expression of micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010150 (miR\u2010150), and then restored miR\u2010150 expression at physiologic levels in <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> cell lines Daudi, Raji, <jats:styled-content style=\"fixed-case\">BJAB<\/jats:styled-content>, and Ramos. The results showed that re\u2010expression of miR\u2010150 reduced proliferation of Daudi and Raji cells. Furthermore, Daudi and Raji, both of which are of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive germinal center B\u2010cell origin, transduced with miR\u2010150 can be rescued to differentiate toward B\u2010cell terminal stage. However, no significant changes were observed in <jats:styled-content style=\"fixed-case\">BJAB<\/jats:styled-content> or Ramos cells, which are of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010negative germinal center B\u2010cell origin. Of note, re\u2010expression of miR\u2010150 also resulted in decreasing c\u2010Myb protein levels. Additionally, c\u2010Myb knockdown in Daudi and Raji cell lines recapitulated the partial characteristics similar to that caused by re\u2010expression of miR\u2010150. Taken together, our findings show that miR\u2010150 can induce <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> differentiation by targeting c\u2010Myb.<\/jats:p>","DOI":"10.1111\/cas.12156","type":"journal-article","created":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T07:03:18Z","timestamp":1364194998000},"page":"826-834","source":"Crossref","is-referenced-by-count":42,"title":["Re\u2010expression of micro<scp>RNA<\/scp>\u2010150 induces <scp>EBV<\/scp>\u2010positive <scp>B<\/scp>urkitt lymphoma differentiation by modulating c\u2010Myb <i>in vitro<\/i>"],"prefix":"10.1111","volume":"104","author":[{"given":"Shaohong","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pathology Nanfang Hospital affiliated to Southern Medical University Guangzhou 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