{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:28:26Z","timestamp":1758709706006},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>Follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>) frequently transforms into diffuse large B\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>). To clarify the associated clinicopathological prognostic parameters, we examined the correlation of 11 histopathological parameters with progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) and overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) in 107 consecutive patients who had <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> with pre\u2010existing (asynchronous) or synchronous <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>. The patients comprised 58 men and 49 women with a median age of 56\u00a0years. For <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>, the complete response rate was 81%, overall response rate was 88%, and 5\u2010year <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> rates were 55% and 79%, respectively. Immunohistochemical analysis of the <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> component revealed the following positivity rates: <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>10, 64%; Bcl\u20102, 83%; Bcl\u20106, 88%; <jats:styled-content style=\"fixed-case\">MUM1<\/jats:styled-content>, 42%; <jats:styled-content style=\"fixed-case\">GCB<\/jats:styled-content>, 82%; <jats:styled-content style=\"fixed-case\">cM<\/jats:styled-content>yc index \u226580%, 17%; and Ki\u201067 index \u226590%, 19%. <jats:styled-content style=\"fixed-case\"><jats:italic>IGH\/BCL2<\/jats:italic><\/jats:styled-content> fusion was positive in 57% of DLBCL cases. In univariate analyses, asynchronous <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> (24%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.021), 100% proportion of <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> (29%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004), Bcl\u20102 positivity (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04), and high Ki\u201067 index (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) were significantly correlated with shorter <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>. Asynchronous <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003), 100% proportion of <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001), and high Ki\u201067 index (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) were significantly correlated with shorter <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>. In a multivariate analysis, asynchronous <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.035) and 100% proportion of <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.016) were significantly correlated with shorter <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>. Thus, asynchronism and 100% proportion of <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>, that is, FL relapsed as pure <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>, or <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> at different sites, were significant predictors of unfavorable outcome of patients with <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> transformed from <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cas.12158","type":"journal-article","created":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T07:03:19Z","timestamp":1364194999000},"page":"952-957","source":"Crossref","is-referenced-by-count":6,"title":["Clinicopathological prognostic indicators in 107 patients with diffuse large B\u2010cell lymphoma transformed from follicular lymphoma"],"prefix":"10.1111","volume":"104","author":[{"given":"Akiko M.","family":"Maeshima","sequence":"first","affiliation":[{"name":"Department of Pathology and Clinical Laboratory National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Clinical Laboratory National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suguru","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensei","family":"Tobinai","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Tsuda","sequence":"additional","affiliation":[{"name":"Department of 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