{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:17:43Z","timestamp":1790691463791,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T00:00:00Z","timestamp":1368576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>\n                    Global histone modification patterns correlate with tumor phenotypes and prognostic factors in multiple tumor types. Recent studies suggest that aberrant histone modifications play an important role in cancer. However, the effects of global epigenetic rearrangements on cell functions remain poorly understood. In this study, we show that the histone H3 lysine 9 (H3K9) methyltransferase\n                    <jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>\n                    39H1 is clearly involved in regulating cell migration\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Overexpression of wild\u2010type\n                    <jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>\n                    39H1, but not enzymatically inactive\n                    <jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>\n                    39H1, activated migration in breast and colorectal cancer cells. Inversely, migration was reduced by knockdown of\n                    <jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>\n                    39H1 or chemical inhibition by chaetocin. In addition, H3K9 trimethylation (H3K9me3) was specifically increased in invasive regions of colorectal cancer tissues. Moreover, the presence of H3K9me3 positively correlated with lymph node metastasis in colorectal cancer patients. Furthermore, overexpression of\n                    <jats:styled-content style=\"fixed-case\">SUV<\/jats:styled-content>\n                    39H1 drove tumorigenesis in mouse, resulting in a considerable decrease in survival rate. These data indicate that H3K9 trimethylation plays an important role in human colorectal cancer progression, possibly by promoting collective cell invasion.\n                  <\/jats:p>","DOI":"10.1111\/cas.12166","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T11:23:16Z","timestamp":1365074596000},"page":"889-895","source":"Crossref","is-referenced-by-count":137,"title":["Cancer\u2010associated upregulation of histone H3 lysine 9 trimethylation promotes cell motility\n                    <i>in vitro<\/i>\n                    and drives tumor formation\n                    <i>in vivo<\/i>"],"prefix":"10.1111","volume":"104","author":[{"given":"Yuhki","family":"Yokoyama","sequence":"first","affiliation":[{"name":"Department of Molecular Pathology Graduate School of Medicine and Health Science, Osaka University Osaka 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Osaka University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Nuclear Dynamics Laboratory Graduate School of Frontier Biosciences, Osaka University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Graduate School of Medicine, Osaka University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Graduate School of Medicine, Osaka University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Joint Research Laboratory of Molecular Signature Analysis Graduate School of Medicine and Health Science, Osaka 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