{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:34:25Z","timestamp":1791232465262,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T00:00:00Z","timestamp":1368057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>In several malignant tumors including lymphoma, macrophages that infiltrate tumor tissues are called tumor\u2010associated macrophages (<jats:styled-content style=\"fixed-case\">TAM<\/jats:styled-content>s). We discovered that <jats:styled-content style=\"fixed-case\">TAM<\/jats:styled-content>s, especially the <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163<jats:sup>+<\/jats:sup> alternatively activated phenotype (M2), were closely involved with progression of adult T\u2010cell leukemia\/lymphoma (<jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content>). We used <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>68 (a pan\u2010macrophage marker) and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163 (an M2 marker) to immunostain 58 <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content> samples. Statistical analyses showed that a high number of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>68<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">TAM<\/jats:styled-content>s and an increased percentage of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163<jats:sup>+<\/jats:sup> cells among the <jats:styled-content style=\"fixed-case\">TAM<\/jats:styled-content>s were associated with a worse clinical prognosis; multivariate analysis indicated that the percentage of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163<jats:sup>+<\/jats:sup> cells was an independent prognostic factor. We also carried out <jats:italic>in vitro<\/jats:italic> coculture experiments with <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content> cell lines (<jats:styled-content style=\"fixed-case\">ATN<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">TL<\/jats:styled-content>\u2010Mor) and monocyte\u2010derived macrophages and found that direct coculture with M2 macrophages significantly increased BrdU incorporation into <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content> cell lines. A cytokine array analysis showed that macrophage\u2010derived soluble factors including C5a, tumor necrosis factor\u2010\u03b1, growth\u2010related oncogene\u2010\u03b1, <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>1\/I\u2010309, and interleukin\u20106 stimulated <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content> cell lines. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163 expression in macrophages was strongly induced by direct contact with <jats:styled-content style=\"fixed-case\">ATN<\/jats:styled-content>\u20101 cells, and downregulation of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163 in macrophages significantly suppressed growth of cocultured <jats:styled-content style=\"fixed-case\">ATN<\/jats:styled-content>\u20101 cells. These results suggest that interaction between M2 macrophages and lymphoma cells may be an appropriate target in treatment of patients with <jats:styled-content style=\"fixed-case\">ATLL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cas.12167","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T15:23:19Z","timestamp":1365088999000},"page":"945-951","source":"Crossref","is-referenced-by-count":109,"title":["Clinical significance of <scp>CD<\/scp>163<sup>+<\/sup> tumor\u2010associated macrophages in patients with adult T\u2010cell leukemia\/lymphoma"],"prefix":"10.1111","volume":"104","author":[{"given":"Yoshihiro","family":"Komohara","sequence":"first","affiliation":[{"name":"Department of Cell Pathology Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Niino","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Cell Pathology Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Department of Cell Pathology Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasita","family":"Horlad","sequence":"additional","affiliation":[{"name":"Department of Cell Pathology Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Takeya","sequence":"additional","affiliation":[{"name":"Department of Cell Pathology Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1027"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(02)02302-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri978"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.014"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1256"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080108"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2008.03.004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V73.6.1664.1664"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00456.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08051.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1271200"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-242347"},{"key":"e_1_2_7_14_1","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue","author":"Oshima K","year":"2008"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-11-253260"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2010.02514.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905680"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-011-1140-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2011.04096.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1518"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.25"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2370"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.51.93"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-9-177"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2011.01945.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2010.01614.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2011.09.008"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2004.05.017"},{"key":"e_1_2_7_29_1","first-page":"RA87","article-title":"Growth related oncogene\u2010alpha (GRO\u2010alpha): roles in atherosclerosis, angiogenesis and other inflammatory conditions","volume":"13","author":"Bechara C","year":"2007","journal-title":"Med Sci Monit"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(97)01215-4"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.00972.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-3-22"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-11-0850"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.12.015"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.5A6871.2006"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/35051594"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.12.8183"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-167064"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2009.01326.x"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1646-4"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcas.12167","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.12167","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.12167","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.12167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T15:59:06Z","timestamp":1693843146000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.12167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,9]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/cas.12167"],"URL":"https:\/\/doi.org\/10.1111\/cas.12167","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,9]]}}}