{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:13:42Z","timestamp":1791170022547,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,6,4]],"date-time":"2013-06-04T00:00:00Z","timestamp":1370304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2013,8]]},"abstract":"\n Tumor associated macrophages (\n TAM<\/jats:styled-content>\n s) are the most abundant cancer stromal cells educated by tumor microenvironment to acquire trophic functions facilitating angiogenesis, matrix breakdown and cancer cell motility. Tumor associated macrophages have anti\u2010inflammatory properties or \u201calternatively\u201d activated (\n M<\/jats:styled-content>\n 2) phenotype expressing\n CD<\/jats:styled-content>\n 204 and\/or\n CD<\/jats:styled-content>\n 163. To know the role of\n TAM<\/jats:styled-content>\n s in the growth and progression of esophageal squamous cell carcinomas (\n ESCC<\/jats:styled-content>\n s), we calculated intratumoral\n CD<\/jats:styled-content>\n 204,\n CD<\/jats:styled-content>\n 163 or\n CD<\/jats:styled-content>\n 68 expressing macrophage count (\n M<\/jats:styled-content>\n \u03d5\n C<\/jats:styled-content>\n ) and\n CD<\/jats:styled-content>\n 34\u2010positive microvessel density (\n MVD<\/jats:styled-content>\n ) by immunohistochemistry in 70 cases of surgically resected\n ESCC<\/jats:styled-content>\n s and compared them with the clinicopathological factors and prognosis of patients.\n M<\/jats:styled-content>\n \u03d5\n C<\/jats:styled-content>\n had positive linear association with\n MVD<\/jats:styled-content>\n . High\n CD<\/jats:styled-content>\n 204\n +<\/jats:sup>\n M<\/jats:styled-content>\n \u03d5\n C<\/jats:styled-content>\n were significantly correlated with more malignant phenotypes including depth of tumor invasion, lymph and blood vessel invasion, lymph node metastasis as well as clinical stages. On the other hand,\n CD<\/jats:styled-content>\n 163\n +<\/jats:sup>\n M<\/jats:styled-content>\n \u03d5\n C<\/jats:styled-content>\n did not associate with these clinicopathological factors with the exception of depth of tumor invasion and blood vessel invasion. Patients with high\n CD<\/jats:styled-content>\n 204\n +<\/jats:sup>\n M<\/jats:styled-content>\n \u03d5\n C ESCC<\/jats:styled-content>\n s showed poor disease\u2010free survival (\n P\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 0.021). Conditioned media of five\n ESCC<\/jats:styled-content>\n cell lines (\n TE<\/jats:styled-content>\n \u20108, \u20109, \u201010, \u201011 and \u201015) induced m\n RNA<\/jats:styled-content>\n as well as protein expression of\n CD<\/jats:styled-content>\n 204 but not of\n CD<\/jats:styled-content>\n 163 with upregulation of\n \n vascular endothelial growth factor\u2010\n A<\/jats:styled-content>\n <\/jats:italic>\n m\n RNA<\/jats:styled-content>\n in\n TPA<\/jats:styled-content>\n treated human acute monocytic leukemia cell line\n THP<\/jats:styled-content>\n \u20101. These results overall indicate that\n CD<\/jats:styled-content>\n 204 is a useful marker for\n TAM<\/jats:styled-content>\n s contributing to the angiogenesis, progression and prognosis of\n ESCC<\/jats:styled-content>\n s whose specific tumor microenvironment may educate macrophages to be\n CD<\/jats:styled-content>\n 204\n +<\/jats:sup>\n M<\/jats:styled-content>\n 2\n TAM<\/jats:styled-content>\n s.\n <\/jats:p>","DOI":"10.1111\/cas.12188","type":"journal-article","created":{"date-parts":[[2013,5,4]],"date-time":"2013-05-04T12:59:30Z","timestamp":1367672370000},"page":"1112-1119","source":"Crossref","is-referenced-by-count":166,"title":["Tumor associated macrophage expressing\n CD<\/scp>\n 204 is associated with tumor aggressiveness of esophageal squamous cell carcinoma"],"prefix":"10.1111","volume":"104","author":[{"given":"Manabu","family":"Shigeoka","sequence":"first","affiliation":[{"name":"Division of Pathology Kobe University Graduate School of Medicine Kobe 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