{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:07:15Z","timestamp":1791223635545,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T00:00:00Z","timestamp":1371427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>\n                    It has been more than 30\u00a0years since the discovery of human\n                    <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                    \u2010lymphotropic virus type 1 (\n                    <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\n                    \u20101), the first human retrovirus identified. Human T\u2010lymphotropic virus type 1 infects 15\u201320 million people worldwide causing two major diseases: adult\n                    <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\n                    \u2010cell leukemia\/lymphoma and\n                    <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\n                    \u20101\u2010associated myelopathy\/tropical spastic paraparesis. Human T\u2010lymphotropic virus type 1 establishes several decades of latent infection, during which viral\u2013host interaction determines disease segregation. This review highlights non\u2010structural proteins that are encoded on the viral genome and manage latent infection. Latent infection is a key in\n                    <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\n                    pathology, so that effective inhibition of these proteins might lead to successful disease management.\n                  <\/jats:p>","DOI":"10.1111\/cas.12190","type":"journal-article","created":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T05:10:23Z","timestamp":1367989823000},"page":"983-988","source":"Crossref","is-referenced-by-count":5,"title":["Human\n                    <scp>T<\/scp>\n                    \u2010lymphotropic virus type 1 non\u2010structural proteins: Requirements for latent infection"],"prefix":"10.1111","volume":"104","author":[{"given":"Risaku","family":"Fukumoto","sequence":"first","affiliation":[{"name":"Scientific Research Department Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences  Bethesda Maryland 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