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This study shows that the incidence of thymic lymphoma in p53\u2010null mice is less frequent in the <jats:styled-content style=\"fixed-case\"><jats:italic>Aml1<jats:sup>+\/\u2212<\/jats:sup><\/jats:italic><\/jats:styled-content> than in the <jats:styled-content style=\"fixed-case\"><jats:italic>Aml1<jats:sup>+\/+<\/jats:sup><\/jats:italic><\/jats:styled-content> background. <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>1 is upregulated in p53\u2010null mouse bone\u2010marrow cells and embryonic fibroblasts. In the steady state, p53 binds to and inhibits the distal <jats:styled-content style=\"fixed-case\"><jats:italic>AML1<\/jats:italic><\/jats:styled-content> promoter. When the cells are exposed to stresses, p53 is released from the distal <jats:styled-content style=\"fixed-case\"><jats:italic>AML1<\/jats:italic><\/jats:styled-content> promoter, resulting in upregulation of <jats:styled-content style=\"fixed-case\"><jats:italic>AML1<\/jats:italic><\/jats:styled-content>. Overexpression of <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>1 stimulates T\u2010lymphocyte proliferation. These results suggest that upregulation of <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>1 induced by loss of p53 promotes lymphoid\u2010cell proliferation, thereby inducing lymphoma development.<\/jats:p>","DOI":"10.1111\/cas.12199","type":"journal-article","created":{"date-parts":[[2013,5,17]],"date-time":"2013-05-17T07:51:09Z","timestamp":1368777069000},"page":"1033-1038","source":"Crossref","is-referenced-by-count":10,"title":["Roles of <scp>AML<\/scp>1\/<scp>RUNX<\/scp>1 in T\u2010cell malignancy induced by loss of p53"],"prefix":"10.1111","volume":"104","author":[{"given":"Kimiko","family":"Shimizu","sequence":"first","affiliation":[{"name":"Division of Hematological Malignancy National Cancer Center Research Institute Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutsune","family":"Yamagata","sequence":"additional","affiliation":[{"name":"Division of Hematological Malignancy National Cancer Center Research Institute Tokyo 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