{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T18:41:28Z","timestamp":1774896088975,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:00:00Z","timestamp":1385510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:p>The <jats:styled-content style=\"fixed-case\">MIB<\/jats:styled-content>\u20101 labeling index, which is based on Ki67 immunostaining, is widely used to evaluate the proliferation of tumor cells in lymphoma. However, its clinical significance has not been fully assessed. We retrospectively evaluated the prognostic impact of the <jats:styled-content style=\"fixed-case\">MIB<\/jats:styled-content>\u20101 labeling index at the time of diagnosis, in 98 patients with follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>) grade 1\u20133b who were treated uniformly with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone (R\u2010<jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content>) therapy. The 5\u2010year progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) for an <jats:styled-content style=\"fixed-case\">MIB<\/jats:styled-content>\u20101 labeling index of \u226510% (<jats:italic>n<\/jats:italic>\u00a0=\u00a060) and &lt;10% (<jats:italic>n<\/jats:italic>\u00a0=\u00a038) was 35% and 61%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.015). The 5\u2010year overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) for an <jats:styled-content style=\"fixed-case\">MIB<\/jats:styled-content>\u20101 labeling index of \u226510% and &lt;10% was 77% and 92%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.025). Pathological grading was not correlated with <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>. In multivariate analysis, an <jats:styled-content style=\"fixed-case\">MIB<\/jats:styled-content>\u20101 labeling index of \u226510% was independently associated with poor PFS and OS. In conclusion, an <jats:styled-content style=\"fixed-case\">MIB<\/jats:styled-content>\u20101 labeling index of 10% is a useful cut\u2010off level for predicting the prognosis of patients with FL.<\/jats:p>","DOI":"10.1111\/cas.12288","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T21:47:06Z","timestamp":1381528026000},"page":"1670-1674","source":"Crossref","is-referenced-by-count":11,"title":["<scp>MIB<\/scp>\u20101 labeling index as a prognostic factor for patients with follicular lymphoma treated with rituximab plus <scp>CHOP<\/scp> therapy"],"prefix":"10.1111","volume":"104","author":[{"given":"Eri","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology Yokohama City University Graduate School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Sakata","sequence":"additional","affiliation":[{"name":"Pathology Project for Molecular Targets The Cancer Institute Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Tsuyama","sequence":"additional","affiliation":[{"name":"Division of Pathology The Cancer Institute Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Pathology Project for Molecular Targets The Cancer Institute Japanese Foundation for Cancer Research Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Hematology Yokohama City University Medical Center Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuho","family":"Miyashita","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Immunology Fujisawa City Hospital Fujisawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Department of Hematology Yokohama City University Medical Center Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Takasaki","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Kanagawa Cancer Center Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Hematology Yokohama City University Medical Center Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chizuko","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Kanagawa Cancer Center Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Koharazawa","sequence":"additional","affiliation":[{"name":"Department of Hematology Yamato City Hospital Yamato Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumichi","family":"Fujimaki","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Immunology Fujisawa City Hospital Fujisawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Hematology Shizuoka Red Cross Hospital Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Harano","sequence":"additional","affiliation":[{"name":"Department of 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