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We analyzed the <jats:styled-content style=\"fixed-case\">IDH<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">IDH<\/jats:styled-content>2 mutations of enchondroma, hemangioma and anaplastic astrocytoma tissues and the same somatic mosaic mutation in <jats:styled-content style=\"fixed-case\">IDH<\/jats:styled-content>2 gene was identified in all these tissues. In addition, we identified additional mutation of the <jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>53 gene in anaplastic astrocytoma tissue but not in other benign tumors. This is the first report of the detection of an identical <jats:styled-content style=\"fixed-case\">IDH<\/jats:styled-content>2 mutation in multiple tissues and <jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>53 mutation in anaplastic astrocytoma in a patient with Maffucci syndrome. This case is unique and supports the <jats:styled-content style=\"fixed-case\">IDH<\/jats:styled-content>2\u2010dependent genetic pathway and second\u2010hit model for gliomagenesis.<\/jats:p>","DOI":"10.1111\/cas.12337","type":"journal-article","created":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T14:37:19Z","timestamp":1387291039000},"page":"359-362","source":"Crossref","is-referenced-by-count":26,"title":["<scp>IDH<\/scp>2 and <scp>TP<\/scp>53 mutations are correlated with gliomagenesis in a patient with Maffucci syndrome"],"prefix":"10.1111","volume":"105","author":[{"given":"Kunihiko","family":"Moriya","sequence":"first","affiliation":[{"name":"Department of Pediatrics Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika K.","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Regional Innovation Tohoku University Graduate School of Medicine Sendai 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