{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:15:30Z","timestamp":1787724930894,"version":"build-2784847793"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,30]],"date-time":"2014-03-30T00:00:00Z","timestamp":1396137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:p>Many studies have demonstrated that microRNA\u2010210 (miR\u2010210) expression is intensively upregulated in hypoxic states and differentially regulated in most types of cancer cells. However, the clinical significance of miR\u2010210 and its effects on the response of leukemic cells to chemotherapeutic drugs in childhood acute lymphoblastic leukemia (ALL) remain unknown. In the current study, using real\u2010time qRT\u2010PCR to detect miR\u2010210 expression in bone marrow samples from 114 children at initial diagnosis of ALL, we investigated the prognostic significance of miR\u2010210 and determined its associations with common clinical characteristics and treatment outcome. We further examined its effect on the response to chemotherapeutic drugs in the Reh and RS4;11 cell lines. Results showed that miR\u2010210 expression was significantly lower in patients suffering from relapse and induction failure than in other patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Using the receiver operating characteristic curve, 3.8243 was selected as the cut\u2010off value of miR\u2010210 expression in our test cohort (38 cases). A significantly poorer treatment outcome (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) was found in the low\u2010expression group and verified in the validation cohort (76 cases, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Patients with low expression of miR\u2010210 and positive minimal residual disease at the end of induction had a much higher rate of relapse or induction failure (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.001). Increasing\/decreasing miR\u2010210 expression using agomir\/antagomir could enhance or reduce the response of Reh cells and RS4;11 cells to daunorubicin\/dexamethasone\/L\u2010asparaginase and daunorubicin\/dexamethasone\/vincristine, respectively. In conclusion, miR\u2010210 may be a good prognostic factor and a useful predictor of drug sensitivity, and is a potential therapeutic target for pediatric ALL.<\/jats:p>","DOI":"10.1111\/cas.12370","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T10:38:40Z","timestamp":1392633520000},"page":"463-472","source":"Crossref","is-referenced-by-count":47,"title":["Effect of micro<scp>RNA<\/scp>\u2010210 on prognosis and response to chemotherapeutic drugs in pediatric acute lymphoblastic leukemia"],"prefix":"10.1111","volume":"105","author":[{"given":"Yanyan","family":"Mei","sequence":"first","affiliation":[{"name":"Key Laboratory of Major Diseases in Children (Capital Medical University) Ministry of Education National Key Discipline of Pediatrics Ministry of Education Hematology Center Beijing Children's Hospital Capital Medical University Beijing 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