{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T12:13:57Z","timestamp":1783426437389,"version":"3.54.6"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Diffuse large B\u2010cell lymphoma (DLBCL<\/jats:styled-content>) displays striking heterogeneity at the clinical, genetic and molecular levels. Subtypes include germinal center B\u2010cell\u2010like (GCB<\/jats:styled-content>) DLBCL<\/jats:styled-content> and activated B\u2010cell\u2010like (ABC<\/jats:styled-content>) DLBCL<\/jats:styled-content>, according to microarray analysis, and germinal center type or non\u2010germinal center type by immunohistochemistry. Although some reports have described genomic aberrations based upon microarray classification system, genomic aberrations based upon immunohistochemical classifications have rarely been reported. The present study aimed to ascertain the relationship between genomic aberrations and subtypes identified by immunohistochemistry, and to study the pathogenetic character of Chinese DLBCL<\/jats:styled-content>. We conducted immunohistochemistry using antibodies against CD<\/jats:styled-content>10, BCL<\/jats:styled-content>6 and MUM<\/jats:styled-content>1 in 59 samples of DLBCL<\/jats:styled-content> from Chinese patients, and then performed microarray\u2010based comparative genomic hybridization for each case. Characteristic genomic differences were found between GCB<\/jats:styled-content> and non\u2010GCB DLBCL<\/jats:styled-content> from the array data. The GCB<\/jats:styled-content> type was characterized by more gains at 7q (7q22.1, P\u00a0<\/jats:italic><\u00a00.05) and losses at 16q (P\u00a0<\/jats:italic>\u2264\u00a00.05), while the non\u2010GCB<\/jats:styled-content> type was characterized by gains at 11q24.3 and 3q13.2 (P\u00a0<\/jats:italic><\u00a00.05). We found completely different mutations in BCL<\/jats:styled-content>6+ and BCL<\/jats:styled-content>6\u2212 non\u2010GCB<\/jats:styled-content> type DLBCL<\/jats:styled-content>, whereby the BCL<\/jats:styled-content>6\u2212 group had a higher number of gains at 1q and a loss at 14q32.13 (P\u00a0<\/jats:italic>\u2264\u00a00.005), while the BCL<\/jats:styled-content>6+ group showed a higher number of gains at 14q23.1 (P\u00a0<\/jats:italic>=\u00a00.15) and losses at 6q (P\u00a0<\/jats:italic>=\u00a00.07). The BCL<\/jats:styled-content>6\u2212 group had a higher frequency of genomic imbalances compared to the BCL<\/jats:styled-content>6+ group. In conclusion, the BCL<\/jats:styled-content>6+ and BCL<\/jats:styled-content>6\u2212 non\u2010GCB<\/jats:styled-content> type of DLBCL<\/jats:styled-content> appear to have different mechanisms of pathogenesis.<\/jats:p>","DOI":"10.1111\/cas.12378","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T10:38:41Z","timestamp":1392633521000},"page":"481-489","source":"Crossref","is-referenced-by-count":9,"title":["Array\u2010comparative genomic hybridization profiling of immunohistochemical subgroups of diffuse large B\u2010cell lymphoma shows distinct genomic alterations"],"prefix":"10.1111","volume":"105","author":[{"given":"Ying","family":"Guo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Cancer Biology Department of Pathology Xijing Hospital and School of Basic Medicine Fourth Military Medical University Xi'an China"},{"name":"Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Information Engineering Graduate School of Engineering, Mie University Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivasundaram","family":"Karnan","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Miyata","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Kurume University Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Seto","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan"},{"name":"Department of Cancer Genetics Nagoya University Graduate School of Medicine at Aichi Cancer Center Research Institute Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1732008100"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.5858\/2006-130-1819-ICODNT","article-title":"Immunohistochemical classification of de novo, transformed, and relapsed diffuse large B\u2010cell lymphoma into germinal center B\u2010cell and nongerminal center B\u2010cell subtypes correlates with gene expression profile and patient survival","volume":"130","author":"Haarer CF","year":"2006","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0542"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.6.2084"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3773"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1399"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2279"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.4.945"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404856"}],"container-title":["Cancer 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