{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:08:21Z","timestamp":1761217701800},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Primary intraocular lymphoma (PIOL<\/jats:styled-content>) is a rare lymphoma. Because of difficulties in obtaining tissue samples, little is known about the disease's genetic features. In order to clarify these features, we carried out single nucleotide polymorphism array karyotyping of IOL<\/jats:styled-content> using genomic DNA<\/jats:styled-content> extracted from vitreous fluid. We analyzed 33 samples of IOL<\/jats:styled-content>s consisting of 16 PIOL<\/jats:styled-content>s, 12 IOL<\/jats:styled-content>s with a central nervous system (CNS<\/jats:styled-content>) lesion at diagnosis (IOCNSL<\/jats:styled-content>), and five secondary IOL<\/jats:styled-content>s following systemic lymphoma. All were B\u2010cell type. We identified recurrent copy number (CN<\/jats:styled-content>) gain regions in PIOL<\/jats:styled-content>s, most frequently on chromosome 1q followed by 18q and 19q. Chromosome 6q was the most frequent loss region. Although these CN<\/jats:styled-content> gain regions of PIOL<\/jats:styled-content> were in common with those of IOCNSL<\/jats:styled-content>, loss of 6q22.33 containing PTPRK<\/jats:styled-content><\/jats:italic> and 9p21.3 containing CDKN<\/jats:styled-content>2A<\/jats:italic> were more frequently deleted in IOCNSL<\/jats:styled-content>. Large CN<\/jats:styled-content> loss in 6q was detected in three of four PIOL<\/jats:styled-content> patients who had early CNS<\/jats:styled-content> development and short survival periods, whereas long\u2010term survivors did not have such deletions. There was a correlation between gain of the IL<\/jats:styled-content>\u201010<\/jats:italic> gene located on 1q and intravitreal interleukin\u201010 concentration, which was higher in IOL<\/jats:styled-content> than in benign uveitis. The results suggest that IOCNSL<\/jats:styled-content> is a highly malignant form of PIOL<\/jats:styled-content> that infiltrates into the CNS<\/jats:styled-content> at an early stage. They also indicate that genetic differences between PIOL<\/jats:styled-content> and primary CNS<\/jats:styled-content> lymphoma need to be clarified.<\/jats:p>","DOI":"10.1111\/cas.12388","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T05:26:40Z","timestamp":1393392400000},"page":"592-599","source":"Crossref","is-referenced-by-count":25,"title":["High\u2010resolution genomic copy number profiling of primary intraocular lymphoma by single nucleotide polymorphism microarrays"],"prefix":"10.1111","volume":"105","author":[{"given":"Ludan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiko","family":"Sato\u2010Otsubo","sequence":"additional","affiliation":[{"name":"Cancer Genomics Project University of Tokyo Tokyo Japan"},{"name":"Department of Pathology and 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