{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:12:14Z","timestamp":1791825134353,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T00:00:00Z","timestamp":1397952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>This study investigated whether conformal radiotherapy affects hepatitis B virus (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>) reactivation, and the risk factors for <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> reactivation in patients with <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content>\u2010related hepatocellular carcinoma (<jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content>). Sixty\u2010nine patients with <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> were included in this retrospective study. Before radiotherapy (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>), all patients underwent imaging examinations and some baseline examinations, including <jats:styled-content style=\"fixed-case\">CBC<\/jats:styled-content>, liver function test, renal function test, \u03b1\u2010fetoprotein level, hepatitis B (<jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content>) surface antigen, <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content> surface Ab, <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content> e antigen, <jats:styled-content style=\"fixed-case\">HB<\/jats:styled-content> e Ab, and serum <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> quantification. During the period of <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> and at least 16\u00a0weeks after the end of <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CBC<\/jats:styled-content>s were carried out weekly and the other tests were monitored monthly or more frequently if necessary. The clinical features and dosimetric parameters of <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> were recorded. Univariate and multivariate logistic regression algorithms were used to analyze the risk factors of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> reactivation. The incidence of complications in the study population was as follows: radiation\u2010induced liver disease, 17.4%; <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> reactivation, 24.6%; and <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> reactivation\u2010induced hepatitis, 21.7%. The <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> level and dose volume parameters including normal liver volume, V20, and mean dose were associated with <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> reactivation. There was a relatively high incidence of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> reactivation in <jats:styled-content style=\"fixed-case\">HCC<\/jats:styled-content> patients after the end of conformal <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>. The serum <jats:styled-content style=\"fixed-case\">HBV DNA<\/jats:styled-content> level and some dosimetric parameters related to normal liver, including normal liver volume, V20, and mean dose, were the prognosis factors of <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> reactivation and should be carefully considered before conformal <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cas.12400","type":"journal-article","created":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T08:06:53Z","timestamp":1395475613000},"page":"697-703","source":"Crossref","is-referenced-by-count":29,"title":["Risk factors for hepatitis B virus reactivation after conformal radiotherapy in patients with hepatocellular carcinoma"],"prefix":"10.1111","volume":"105","author":[{"given":"Wei","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology VI Shandong Cancer Hospital Shandong Academy of Medical 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