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Until recently, molecular characterization of <jats:styled-content style=\"fixed-case\">MLN<\/jats:styled-content> was mainly based on cytogenetics\/fluorescence in situ hybridization, allele copy number, and m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression, approaches that yielded scanty gene mutation information. Use of massive parallel sequencing technologies has changed this outcome, and now many gene mutations have been discovered. Some of these are considerably frequent in, and substantially specific to, distinct <jats:styled-content style=\"fixed-case\">MLN<\/jats:styled-content> subtypes, and occur at single or several hotspots. They include the <jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>600<jats:styled-content style=\"fixed-case\">E <\/jats:styled-content><jats:italic><jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content><\/jats:italic> mutation in hairy cell leukemia, the <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>265<jats:styled-content style=\"fixed-case\">P <\/jats:styled-content><jats:italic><jats:styled-content style=\"fixed-case\">MYD<\/jats:styled-content>88<\/jats:italic> mutation in <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>aldenstr\u00f6m macroglobulinemia, the <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>17<jats:styled-content style=\"fixed-case\">V <\/jats:styled-content><jats:italic><jats:styled-content style=\"fixed-case\">RHOA<\/jats:styled-content><\/jats:italic> mutation in angioimmunoblastic <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell lymphoma and peripheral <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell lymphoma, not otherwise specified, and the <jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content>640<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>\/\/<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>661<jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\/\/<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>647<jats:styled-content style=\"fixed-case\">I <\/jats:styled-content><jats:italic><jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3<\/jats:italic> mutations in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010cell large granular lymphocytic leukemia. Detecting these mutations is highly valuable in diagnosing <jats:styled-content style=\"fixed-case\">MLN<\/jats:styled-content> subtypes. Defining these mutations also sheds light on the molecular pathogenesis of <jats:styled-content style=\"fixed-case\">MLN<\/jats:styled-content>, furthering development of molecular targeting therapies. In this review, we focus on the disease\u2010specific gene mutations in <jats:styled-content style=\"fixed-case\">MLN<\/jats:styled-content> discovered by recent massive sequencing technologies.<\/jats:p>","DOI":"10.1111\/cas.12408","type":"journal-article","created":{"date-parts":[[2014,4,2]],"date-time":"2014-04-02T04:57:13Z","timestamp":1396414633000},"page":"623-629","source":"Crossref","is-referenced-by-count":14,"title":["Disease\u2010specific mutations in mature lymphoid neoplasms: Recent advances"],"prefix":"10.1111","volume":"105","author":[{"given":"Mamiko","family":"Sakata\u2010Yanagimoto","sequence":"first","affiliation":[{"name":"Department of Hematology Graduate School of Comprehensive Human Sciences University of Tsukuba Tsukuba Japan"},{"name":"Department of Hematology Faculty of Medicine University of Tsukuba Tsukuba Japan"},{"name":"Department of Hematology University of Tsukuba Hospital Tsukuba 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