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HUHS<\/jats:styled-content>1015 induced both necrosis and apoptosis of MSTO<\/jats:styled-content>\u2010211H and NCI<\/jats:styled-content>\u2010H2052 cells. HUHS<\/jats:styled-content>1015 upregulated expression of mRNA<\/jats:styled-content>s for Puma, Hrk, and Noxa in MSTO<\/jats:styled-content>\u2010211H and NCI<\/jats:styled-content>\u2010H2052 cells, suggesting HUHS<\/jats:styled-content>1015\u2010induced mitochondrial apoptosis. HUHS<\/jats:styled-content>1015 clearly suppressed tumor growth in mice inoculated with NCI<\/jats:styled-content>\u2010H2052 cells. 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