{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:03:43Z","timestamp":1787497423135,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"Health and Labour Sciences Research Grants of Japan (Research on Risk of Chemical Substance 21340601)","award":["H25-kagaku-ippan-004"],"award-info":[{"award-number":["H25-kagaku-ippan-004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2014,7]]},"abstract":"\n Multiwalled carbon nanotubes (\n MWCNT<\/jats:styled-content>\n ) have a fibrous structure similar to asbestos, raising concern that\n MWCNT<\/jats:styled-content>\n exposure may lead to asbestos\u2010like diseases. Previously we showed that\n MWCNT<\/jats:styled-content>\n translocated from the lung alveoli into the pleural cavity and caused mesothelial proliferation and fibrosis in the visceral pleura. Multiwalled carbon nanotubes were not found in the parietal pleura, the initial site of development of asbestos\u2010caused pleural diseases in humans, probably due to the short exposure period of the study. In the present study, we extended the exposure period to 24\u00a0weeks to determine whether the size and shape of\n MWCNT<\/jats:styled-content>\n impact on deposition and lesion development in the pleura and lung. Two different\n MWCNT<\/jats:styled-content>\n s were chosen for this study: a larger sized needle\u2010like\n MWCNT<\/jats:styled-content>\n (\n MWCNT<\/jats:styled-content>\n \u2010\n L<\/jats:styled-content>\n ;\n l\u00a0<\/jats:italic>\n =\u00a08\u00a0\u03bcm,\n d\u00a0<\/jats:italic>\n =\u00a0150\u00a0nm), and a smaller sized\n MWCNT<\/jats:styled-content>\n (\n MWCNT<\/jats:styled-content>\n \u2010\n S<\/jats:styled-content>\n ;\n l<\/jats:italic>\n \u00a0=\u00a03\u00a0\u03bcm,\n d<\/jats:italic>\n \u00a0=\u00a015\u00a0nm), which forms cotton candy\u2010like aggregates. Both\n MWCNT<\/jats:styled-content>\n \u2010\n L<\/jats:styled-content>\n and\n MWCNT<\/jats:styled-content>\n \u2010\n S<\/jats:styled-content>\n suspensions were administered to the rat lung once every 2\u00a0weeks for 24\u00a0weeks by transtracheal intrapulmonary spraying. It was found that\n MWCNT<\/jats:styled-content>\n \u2010\n L<\/jats:styled-content>\n , but not\n MWCNT<\/jats:styled-content>\n \u2010\n S<\/jats:styled-content>\n , translocated into the pleural cavity, deposited in the parietal pleura, and induced fibrosis and patchy parietal mesothelial proliferation lesions. In addition,\n MWCNT<\/jats:styled-content>\n \u2010\n L<\/jats:styled-content>\n induced stronger inflammatory reactions including increased inflammatory cell number and cytokine\/chemokine levels in the pleural cavity lavage than\n MWCNT<\/jats:styled-content>\n \u2010\n S<\/jats:styled-content>\n . In contrast,\n MWCNT<\/jats:styled-content>\n \u2010\n S<\/jats:styled-content>\n induced stronger inflammation and higher 8\u2010hydroxydeoxyguanosine level in the lung tissue than\n MWCNT<\/jats:styled-content>\n \u2010\n L<\/jats:styled-content>\n . These results suggest that\n MWCNT<\/jats:styled-content>\n \u2010\n L<\/jats:styled-content>\n has higher risk of causing asbestos\u2010like pleural lesions relevant to mesothelioma development.\n <\/jats:p>","DOI":"10.1111\/cas.12437","type":"journal-article","created":{"date-parts":[[2014,5,11]],"date-time":"2014-05-11T06:24:47Z","timestamp":1399789487000},"page":"763-769","source":"Crossref","is-referenced-by-count":71,"title":["Size\u2010 and shape\u2010dependent pleural translocation, deposition, fibrogenesis, and mesothelial proliferation by multiwalled carbon nanotubes"],"prefix":"10.1111","volume":"105","author":[{"given":"Jiegou","family":"Xu","sequence":"first","affiliation":[{"name":"Laboratory of Nanotoxicology Project Nagoya City University Nagoya Japan"},{"name":"Department of Immunology Anhui Medical University College of Basic Medical Sciences Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Laboratory of Nanotoxicology Project Nagoya City University Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Futakuchi","sequence":"additional","affiliation":[{"name":"Department of Molecular Toxicology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamasa","family":"Numano","sequence":"additional","affiliation":[{"name":"Department of Molecular Toxicology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumi","family":"Fukamachi","sequence":"additional","affiliation":[{"name":"Department of Molecular Toxicology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masumi","family":"Suzui","sequence":"additional","affiliation":[{"name":"Department of Molecular Toxicology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toyonori","family":"Omori","sequence":"additional","affiliation":[{"name":"Air Environment Division Environment Management Bureau Ministry of the Environment, Government of Japan Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kanno","sequence":"additional","affiliation":[{"name":"Division of Cellular and Molecular Toxicology National Institute of Health Sciences Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Hirose","sequence":"additional","affiliation":[{"name":"Division of Risk Assessment National Institute of Health Sciences Tokyo 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