{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:31:25Z","timestamp":1761895885067},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T00:00:00Z","timestamp":1403049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>Primary cutaneous \u03b3\u03b4 T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">PCGD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TCL<\/jats:styled-content>) is an aggressive lymphoma consisting of clonal proliferation of mature activated \u03b3\u03b4 T\u2010cells of a cytotoxic phenotype. Because primary cutaneous \u03b3\u03b4 T\u2010cell lymphoma is a rare disease, there are few clinicopathological studies. In addition, T\u2010cell receptor (<jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>) \u03b3\u03b4 cells are typically immunostained in frozen sections or determined by <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>\u03b2 negativity. We retrospectively analyzed 17 primary cutaneous T\u2010cell lymphomas of the \u03b3\u03b4 phenotype (<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>\u2010\u03b3\u03b4) in a clinicopathological and molecular study using paraffin\u2010embedded sections. Among 17 patients, 11 had <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>\u2010\u03b3\u03b4 without subcutaneous panniculitis\u2010like T\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content>) features and six had <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>\u2010\u03b3\u03b4 with <jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content> features. Immunophenotypically, some significant differences were found in <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>56 positivity between our patient series of <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>\u2010\u03b3\u03b4 patients with <jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content> features and <jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content>\u2010\u03b3\u03b4 patients described in the previous literature. A univariate analysis of 17 <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>\u2010\u03b3\u03b4 patients showed that being more than 60\u00a0years old, presence of visceral organ involvement, and small\u2010to\u2010medium cell size were poor prognostic factors. In addition, the 5\u2010year overall survival rate was 42.4% for the <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>\u2010\u03b3\u03b4 patients without <jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content> features and 80.0% for those with <jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content> features. Consequently, there was a strikingly significant difference in overall survival among <jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CTCL<\/jats:styled-content>\u2010\u03b3\u03b4 with <jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content> features and <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>\u2010\u03b3\u03b4 without <jats:styled-content style=\"fixed-case\">SPTCL<\/jats:styled-content> features (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.0005). Our data suggests that an indolent subgroup may exist in <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>\u2010\u03b3\u03b4. Studies on more cases, including those from other countries, are warranted to delineate the clinicopathological features and the significance in these rare lymphomas.<\/jats:p>","DOI":"10.1111\/cas.12439","type":"journal-article","created":{"date-parts":[[2014,5,11]],"date-time":"2014-05-11T10:24:52Z","timestamp":1399803892000},"page":"912-923","source":"Crossref","is-referenced-by-count":18,"title":["Clinicopathological analysis of 17 primary cutaneous T\u2010cell lymphoma of the \u03b3\u03b4 phenotype from <scp>J<\/scp>apan"],"prefix":"10.1111","volume":"105","author":[{"given":"Yuka","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyoshi","family":"Takata","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathophysiology\/Clinical Pathology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuharu","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Pathology Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Nagoya University Hospital Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Ogino","sequence":"additional","affiliation":[{"name":"Department of Pathology Takamatsu Red Cross Hospital Takamatsu 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