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Our analysis was extended to other types of lymphoma including marginal zone lymphoma, follicular lymphoma and diffuse large <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell lymphoma. To determine the presence of clonal heterogeneity, 332 cases were examined using array comparative genomic hybridization analysis. Results showed that incidence of clonal heterogeneity varied from 25% to 69% among different types of lymphoma. Survival analysis revealed that mantle cell lymphoma and diffuse large <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010cell lymphoma with clonal heterogeneity showed significantly poorer prognosis, and that clonal heterogeneity was confirmed as an independent predictor of poor prognosis for both types of lymphoma. Interestingly, 8q24.1 (<jats:styled-content style=\"fixed-case\"><jats:italic>MYC<\/jats:italic><\/jats:styled-content>) gain, 9p21.3 (<jats:styled-content style=\"fixed-case\"><jats:italic>CDKN2A\/2B<\/jats:italic><\/jats:styled-content>) loss and 17p13 (<jats:styled-content style=\"fixed-case\"><jats:italic>TP53<\/jats:italic><\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> <jats:italic>ATP1B2<\/jats:italic><\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> <jats:italic>SAT2<\/jats:italic><\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> <jats:italic>SHBG<\/jats:italic><\/jats:styled-content>) loss were recurrent genomic lesions among various types of lymphoma with clonal heterogeneity, suggesting at least in part that alterations of these genes may play a role in clonal heterogeneity.<\/jats:p>","DOI":"10.1111\/cas.12442","type":"journal-article","created":{"date-parts":[[2014,5,11]],"date-time":"2014-05-11T10:24:52Z","timestamp":1399803892000},"page":"897-904","source":"Crossref","is-referenced-by-count":14,"title":["Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis"],"prefix":"10.1111","volume":"105","author":[{"given":"Miyuki","family":"Suguro","sequence":"first","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Umino","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya 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