{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:53:52Z","timestamp":1790430832347,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T00:00:00Z","timestamp":1403827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["23592459"],"award-info":[{"award-number":["23592459"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>Indoleamine 2,3\u2010dioxygenase (<jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content>) is a tryptophan\u2010catabolizing enzyme that has immunoregulatory functions. Our prior study showed that tumoral <jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content> overexpression is involved in disease progression and impaired patient survival in human ovarian cancer, although its mechanism remains unclear. The purpose of the present study is to clarify the role of <jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content> during the process of peritoneal dissemination of ovarian cancer. Indoleamine 2,3\u2010dioxygenase c<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was transfected into the murine ovarian carcinoma cell line <jats:styled-content style=\"fixed-case\">OV<\/jats:styled-content>2944\u2010<jats:styled-content style=\"fixed-case\">HM<\/jats:styled-content>\u20101, establishing stable clones of <jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content>\u2010overexpressing cells (<jats:styled-content style=\"fixed-case\">HM<\/jats:styled-content>\u20101\u2010<jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content>). Then <jats:styled-content style=\"fixed-case\">HM<\/jats:styled-content>\u20101\u2010<jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content> or control vector\u2010transfected cells (<jats:styled-content style=\"fixed-case\">HM<\/jats:styled-content>\u20101\u2010mock) were i.p. transplanted into syngeneic immunocompetent mice. The <jats:styled-content style=\"fixed-case\">HM<\/jats:styled-content>\u20101\u2010<jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content>\u2010transplanted mice showed significantly shortened survival compared with <jats:styled-content style=\"fixed-case\">HM<\/jats:styled-content>\u20101\u2010mock\u2010transplanted (control) mice. On days 11 and 14 following transplantation, the tumor weight of peritoneal dissemination and ascites volume were significantly increased in <jats:styled-content style=\"fixed-case\">HM<\/jats:styled-content>\u20101\u2010<jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content>\u2010transplanted mice compared with those of control mice. This tumor\u2010progressive effect was coincident with significantly reduced numbers of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells and natural killer cells within tumors as well as increased levels of transforming growth factor\u2010\u03b2 and interleukin\u201010 in ascites. Finally, treatment with the <jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content> inhibitor 1\u2010methyl\u2010tryptophan significantly suppressed tumor dissemination and ascites with reduced transforming growth factor\u2010\u03b2 secretion. These findings showed that tumor\u2010derived <jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content> promotes the peritoneal dissemination of ovarian cancer through suppression of tumor\u2010infiltrating effector <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cell and natural killer cell recruitment and reciprocal enhancement of immunosuppressive cytokines in ascites, creating an immunotolerogenic environment within the peritoneal cavity. Therefore, <jats:styled-content style=\"fixed-case\">IDO<\/jats:styled-content> may be a promising molecular target for the therapeutic strategy of ovarian cancer.<\/jats:p>","DOI":"10.1111\/cas.12445","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T12:11:36Z","timestamp":1400069496000},"page":"966-973","source":"Crossref","is-referenced-by-count":58,"title":["Indoleamine 2,3\u2010dioxygenase promotes peritoneal metastasis of ovarian cancer by inducing an immunosuppressive environment"],"prefix":"10.1111","volume":"105","author":[{"given":"Yuko","family":"Tanizaki","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Toujima","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihisa","family":"Shiro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Mizoguchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Mabuchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetaka","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sawako","family":"Minami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Takikawa","sequence":"additional","affiliation":[{"name":"National Institute for Longevity Sciences National Center for Geriatrics and Gerontology Obu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Ino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Wakayama Medical University Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20138"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1102-991"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2006.00442.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1936"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1586"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.01.019"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-011-9289-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2199"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.09.032"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5380.1191"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21583"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020121"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.8.5396"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2130"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm934"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2671"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-1331"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603477"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4144"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.07.015"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-0991"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(91)90154-4"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/bio.1112"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25961"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)77982-4"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940401)73:7<1882::AID-CNCR2820730718>3.0.CO;2-R"},{"key":"e_1_2_7_28_1","first-page":"1715","article-title":"Expression of IL\u201010 in patients with ovarian carcinoma","volume":"26","author":"Mustea A","year":"2006","journal-title":"Anticancer Res"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047190"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11670-012-0130-y"},{"key":"e_1_2_7_31_1","first-page":"113","article-title":"Indoleamine 2,3\u2010dioxygenase promotes peritoneal dissemination of ovarian cancer through inhibition of natural killer cell function and angiogenesis promotion","volume":"38","author":"Nonaka H","year":"2011","journal-title":"Int J Oncol"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2011.1295"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1093"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2010.04.032"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130066"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0014"},{"key":"e_1_2_7_37_1","unstructured":"1\u2010Methyl\u2010D\u2010Tryptophan in treating patients with metastatic or refractory solid tumors that cannot be removed by surgery. Information provided by National Cancer Institute (NCI).http:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT00567931."}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcas.12445","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.12445","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.12445","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.12445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:38:14Z","timestamp":1696340294000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.12445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,27]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/cas.12445"],"URL":"https:\/\/doi.org\/10.1111\/cas.12445","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,27]]}}}