{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:21:02Z","timestamp":1783488062208,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T00:00:00Z","timestamp":1410134400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Diffuse large B\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>) is the most common subtype of malignant lymphoma. The incidence of Epstein\u2013Barr virus (<jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>)\u2010positive <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> in Asian and Latin American countries ranges from 8 to 10%. The prognosis of patients with <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> is controversial. To compare the clinical outcome of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive and <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010negative patients with <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> in the rituximab era, we analyzed 239 patients with <jats:italic>de novo <\/jats:italic><jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> diagnosed between January 2007 and December 2011. The presence of <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content> in lymphoma cells was detected using <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010encoded <jats:styled-content style=\"fixed-case\">RNA <\/jats:styled-content><jats:italic>in situ<\/jats:italic> hybridization, and it was found that 18 (6.9%) of 260 patients with diagnosed <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> tested positive. Among the 260 cases, 216 cases were treated with rituximab plus chemotherapy, as were 8 <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> patients. The median overall survival and progression\u2010free survival times in patients with <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> were 8.7\u00a0months and 6.8\u00a0months, respectively. The median overall survival and progression\u2010free survival could not be determined in <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010negative <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0002<jats:italic>, P<\/jats:italic>\u00a0&lt;\u00a00.0001, respectively). The outcome of patients with <jats:styled-content style=\"fixed-case\">EBV<\/jats:styled-content>\u2010positive <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> remains poor, even in the rituximab era.<\/jats:p>","DOI":"10.1111\/cas.12467","type":"journal-article","created":{"date-parts":[[2014,6,28]],"date-time":"2014-06-28T09:45:06Z","timestamp":1403948706000},"page":"1170-1175","source":"Crossref","is-referenced-by-count":64,"title":["Clinical outcome of Epstein\u2013Barr virus\u2010positive diffuse large B\u2010cell lymphoma of the elderly in the rituximab era"],"prefix":"10.1111","volume":"105","author":[{"given":"Ai","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Hematology\u2013Oncology School of Medicine Tokai University Isehara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoya","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Medicine Tokai University 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