{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T20:30:19Z","timestamp":1748032219161},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"name":"Faculty research grant of Yonsei University College of Medicine for 2014","award":["3-2014-0115"],"award-info":[{"award-number":["3-2014-0115"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>Thymus and activation\u2010regulated chemokine (<jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content>) can stimulate cancer cell proliferation and migration. The present study evaluated the clinical significance of serum <jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content> in gastric cancer (<jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>). We measured serum <jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content>, macrophage\u2010derived chemokine, monocyte chemotactic protein\u20101 and stem cell factor (<jats:styled-content style=\"fixed-case\">SCF<\/jats:styled-content>) levels using a chemiluminescent immunoassay along the <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> carcinogenesis (normal, high\u2010risk, early <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> [<jats:styled-content style=\"fixed-case\">EGC<\/jats:styled-content>] and advanced <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> [<jats:styled-content style=\"fixed-case\">AGC<\/jats:styled-content>]) in both training (<jats:italic>N<\/jats:italic>\u00a0=\u00a025 per group) and independent validation datasets (90\u00a0normal, 30 high\u2010risk, 50 <jats:styled-content style=\"fixed-case\">EGC<\/jats:styled-content> and 50 <jats:styled-content style=\"fixed-case\">AGC<\/jats:styled-content>). Serum levels were compared among groups using one\u2010way analysis of variance. To evaluate the diagnostic potential of serum <jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>, receiver operating characteristic curve and logistic regression analyses were performed. Correlations between serum <jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> clinicopathological features were analyzed using Spearman's correlation. In the training dataset, serum <jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content> correlated with serum <jats:styled-content style=\"fixed-case\">MDC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> MCP<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">SCF<\/jats:styled-content>. However, only serum <jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SCF<\/jats:styled-content> were significantly higher in cancer groups than non\u2010cancer groups (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). In the validation dataset, serum <jats:styled-content style=\"fixed-case\">TARC<\/jats:styled-content> also increased along the GC carcinogenesis; the <jats:styled-content style=\"fixed-case\">AGC<\/jats:styled-content> group (167.2\u00a0\u00b1\u00a0111.1\u00a0ng\/mL) had significantly higher levels than the <jats:styled-content style=\"fixed-case\">EGC<\/jats:styled-content> (109.1\u00a0\u00b1\u00a067.7\u00a0ng\/mL), the high\u2010risk (66.2\u00a0\u00b1\u00a047.7\u00a0ng\/mL) and the normal (67.5\u00a0\u00b1\u00a036.2\u00a0ng\/mL) groups (Bonferroni, all <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001). Receiver operating characteristic curves and logistic regression demonstrated the remarkable diagnostic potential of serum TARC as a single marker (72.0% sensitivity and 71.1% specificity; cutoff point, 0.37; logistic regression) and in a multiple\u2010marker panel (72.6% sensitivity and 88.2% specificity; cutoff point, 0.54). Spearman's correlation showed that serum TARC was closely correlated with tumor size (\u03b3<jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>\u00a0=\u00a00.227, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.028), T\u2010stage (\u03b3<jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>\u00a0=\u00a00.340, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.001), N\u2010stage (\u03b3<jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>\u00a0=\u00a00.318, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.002) and M\u2010stage (\u03b3<jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>\u00a0=\u00a00.346, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.001). Serum TARC is a promising serum biomarker for GC.<\/jats:p>","DOI":"10.1111\/cas.12505","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T06:41:36Z","timestamp":1409035296000},"page":"1327-1333","source":"Crossref","is-referenced-by-count":12,"title":["Clinical significance of serum thymus and activation\u2010regulated chemokine in gastric cancer: Potential as a serum biomarker"],"prefix":"10.1111","volume":"105","author":[{"given":"Jong\u2010Baeck","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do\u2010Kyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye 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