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Although the overall survival (OS) of patients with ATL has increased marginally because of advances in chemotherapy, further prolongation of survival might be difficult with conventional chemotherapy alone. Promising results have been reported for antiviral therapy using zidovudine and interferon\u2010\u03b1, and, indeed, antiviral therapy is currently the standard treatment for patients with ATL in western countries. Remarkably, the 5\u2010year OS rates are 100% for both the smoldering\u2010type and chronic\u2010type ATL. Recently, treatments for ATL have included allogeneic hematopoietic stem cell transplantation and molecular targeted therapies. Furthermore, the anti\u2010CCR4 monoclonal antibody mogamulizumab has been shown to have marked cytotoxic effects on ATL cells, especially in the leukemic type of ATL. In the lymphoma type of ATL, the response rate may be improved by combining mogamulizumab with chemotherapy. It should be recognized that prevention of infection from carriers of human T\u2010cell leukemia virus type\u2010I and transfer of the virus from mother to infant are crucial issues for the eradication of ATL.<\/jats:p>","DOI":"10.1111\/cas.12617","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T06:10:39Z","timestamp":1421993439000},"page":"344-351","source":"Crossref","is-referenced-by-count":97,"title":["Recent advances in the treatment of adult T\u2010cell leukemia\u2010lymphomas"],"prefix":"10.1111","volume":"106","author":[{"given":"Atae","family":"Utsunomiya","sequence":"first","affiliation":[{"name":"Department of Hematology Imamura Bun\u2010in Hospital Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilseung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Hematology National Kyushu Cancer Center Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Chihara","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Seto","sequence":"additional","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine Kurume Japan"},{"name":"Department of Pharmaceutical Development Immuno\u2010Biological Laboratories Fujioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V50.3.481.481"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.475"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00247"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08051.x"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.4.1160"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702731"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506293322603"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506293322604"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-10-52"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208968"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23181"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2013.57"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2012.02373.x"},{"key":"e_1_2_18_16_1","first-page":"221","volume-title":"Adult T\u2010Cell Leukemia","author":"Shimoyama M","year":"1994"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(91)90087-A"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/101754"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.2101"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.28.0669"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.50.9"},{"key":"e_1_2_18_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyr168"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.9958"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701533"},{"key":"e_1_2_18_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-11-4193"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.92"},{"key":"e_1_2_18_27_1","unstructured":"Hematopoietic Cell Transplantation in Japan.Annual Report of Nationwide Survey 2013. 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