{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:44:34Z","timestamp":1765485874984},"reference-count":57,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI Japan","award":["24300334"],"award-info":[{"award-number":["24300334"]}]},{"name":"MEXT KAKENHI Japan","award":["22133005"],"award-info":[{"award-number":["22133005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>Recent genome\u2010wide <jats:styled-content style=\"fixed-case\">cDNA<\/jats:styled-content> microarray analysis of gene expression profiles in comprehensive tumor types coupled with isolation of cancer tissues by laser\u2010microbeam microdissection have revealed ideal tumor\u2010associated antigens (<jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content>s) that are frequently overexpressed in various cancers including head and neck squamous cell cancer (<jats:styled-content style=\"fixed-case\">HNSCC<\/jats:styled-content>) and lung cancer, but not in most normal tissues except for testis, placenta, and fetal organs. Preclinical studies using <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010transgenic mice and human T cells <jats:italic>in vitro<\/jats:italic> showed that <jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content>\u2010derived <jats:styled-content style=\"fixed-case\">CTL<\/jats:styled-content>\u2010epitope short peptides (<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>s) are highly immunogenic and induce <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A2 or \u2010A24\u2010restricted <jats:styled-content style=\"fixed-case\">CTL<\/jats:styled-content>s. Based on the accumulated evidence, we carried out a phase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> clinical trial of the <jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content> vaccine in advanced 37 <jats:styled-content style=\"fixed-case\">HNSCC<\/jats:styled-content> patients. This study showed a significant induction of <jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content>\u2010specific <jats:styled-content style=\"fixed-case\">CTL<\/jats:styled-content>s in the majority of patients without serious adverse effects. Importantly, clinical responses including a complete response were observed in this study. Another phase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> clinical trial of therapeutic <jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content> vaccine, designed to evaluate the ability of prevention of recurrence, is ongoing in <jats:styled-content style=\"fixed-case\">HNSCC<\/jats:styled-content> patients who have received curative operations. Further studies in human preclinical studies and <jats:italic>in vivo<\/jats:italic> studies using <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> class I transgenic mice showed <jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content>\u2010derived long peptides (<jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>s) have the capacity to induce not only promiscuous <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> class <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\u2010restricted <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T helper type 1 cells but also tumor\u2010specific <jats:styled-content style=\"fixed-case\">CTL<\/jats:styled-content>s through a cross\u2010presentation mechanism. Moreover, we observed an augmentation of <jats:styled-content style=\"fixed-case\">TAA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>\u2010specific T helper type 1 cell responses and tumor antigen\u2010spreading in <jats:styled-content style=\"fixed-case\">HNSCC<\/jats:styled-content> patients vaccinated with TAA\u2010SPs. This accumulated evidence suggests that therapeutic TAA\u2010SPs and <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>s vaccines may provide a promising cancer immunotherapy.<\/jats:p>","DOI":"10.1111\/cas.12650","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T08:04:59Z","timestamp":1425283499000},"page":"505-511","source":"Crossref","is-referenced-by-count":38,"title":["Cancer immunotherapy using novel tumor\u2010associated antigenic peptides identified by genome\u2010wide <scp>cDNA<\/scp> microarray analyses"],"prefix":"10.1111","volume":"106","author":[{"given":"Yasuharu","family":"Nishimura","sequence":"first","affiliation":[{"name":"Department of Immunogenetics Graduate School of Medical Sciences Kumamoto University Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Immunogenetics Graduate School of Medical 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