{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:46:53Z","timestamp":1781700413194,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T00:00:00Z","timestamp":1428278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["22700913"],"award-info":[{"award-number":["22700913"]}]},{"name":"JSPS KAKENHI","award":["24701019"],"award-info":[{"award-number":["24701019"]}]},{"name":"JSPS KAKENHI","award":["25640087"],"award-info":[{"award-number":["25640087"]}]},{"DOI":"10.13039\/100011313","name":"The Tokyo Biochemical Research Foundation","doi-asserted-by":"crossref","award":["TBRF-RF-56"],"award-info":[{"award-number":["TBRF-RF-56"]}],"id":[{"id":"10.13039\/100011313","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:p>Cadmium is a toxic pollutant with occupational and environmental significance, due to its diverse toxic effects. Supramolecules that conjugate and decontaminate toxic metals have potential for use in treatment of cadmium intoxication. In addition, metal\u2010coordinating ability has been postulated to contribute to the cytotoxic effects of anti\u2010tumor agents such as cisplatin or bleomycin. Thiacalixarenes, cyclic oligomers of <jats:italic>p<\/jats:italic>\u2010alkylphenol bridged by sulfur atoms, are supramolecules known to have potent coordinating ability to metal ions. In this study, we show that cadmium\u2010coordinated thiacalix[4]arene tetrasulfate (<jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>4<jats:styled-content style=\"fixed-case\">ATS<\/jats:styled-content>\u2010Cd) exhibits an anti\u2010proliferative effect against T\u2010cell leukemia cells. Cadmium exhibited cytotoxicity with <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><jats:sub>50<\/jats:sub> values ranging from 36 to 129\u00a0\u03bcM against epithelia\u2010derived cancer cell lines, while <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>4<jats:styled-content style=\"fixed-case\">ATS<\/jats:styled-content>\u2010Cd elicited no significant cytotoxicity (<jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><jats:sub>50<\/jats:sub>\u00a0&gt;\u00a0947\u00a0\u03bcM). However, a number of T\u2010cell leukemia cell lines exhibited marked sensitivity to <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>4<jats:styled-content style=\"fixed-case\">ATS<\/jats:styled-content>\u2010Cd. In Jurkat cells, toxicity of <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>4<jats:styled-content style=\"fixed-case\">ATS<\/jats:styled-content>\u2010Cd occurred with an <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><jats:sub>50<\/jats:sub> of 6.9\u00a0\u03bcM, which is comparable to that of 6.5\u00a0\u03bcM observed for cadmium alone. <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>4<jats:styled-content style=\"fixed-case\">ATS<\/jats:styled-content>\u2010Cd induced apoptotic cell death through activation of caspase\u20103 in Jurkat cells. In a xenograft model, <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>4<jats:styled-content style=\"fixed-case\">ATS<\/jats:styled-content>\u2010Cd (13\u00a0mg\/kg) treatment significantly suppressed the tumor growth of Jurkat cells in mice. In addition, <jats:styled-content style=\"fixed-case\">TC<\/jats:styled-content>4<jats:styled-content style=\"fixed-case\">ATS<\/jats:styled-content>\u2010Cd\u2010treated mice exhibited significantly less cadmium accumulation in liver and kidney compared to equimolar cadmium\u2010treated mice. These results suggest that cadmium\u2010coordinated supramolecules may have therapeutic potential for treatment of T\u2010cell leukemia.<\/jats:p>","DOI":"10.1111\/cas.12651","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T14:48:59Z","timestamp":1425394139000},"page":"635-641","source":"Crossref","is-referenced-by-count":23,"title":["Cadmium\u2010coordinated supramolecule suppresses tumor growth of <scp>T<\/scp>\u2010cell leukemia in mice"],"prefix":"10.1111","volume":"106","author":[{"given":"Xiaoping","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Biochemistry Akita University Graduate School of Medicine Akita Japan"},{"name":"Venture Business Laboratory Akita University Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Akita University Graduate School of Medicine Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Akita University Graduate School of Medicine Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Natsui","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Akita University Graduate School of Medicine Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souichi","family":"Koyota","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Akita University Graduate School of Medicine Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Yamada","sequence":"additional","affiliation":[{"name":"Research Center for Engineering Science Graduate School of Engineering and Resource Science Akita University Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Life Science Graduate School of Engineering and Resource Science Akita University Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Hamada","sequence":"additional","affiliation":[{"name":"Applied Chemistry Graduate School of Engineering and Resource Science Akita University Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Akita University Graduate School of Medicine Akita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,6]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"119","volume-title":"Beryllium, Cadmium, Mercury, and Exposures in the Glass Manufacturing Industry. 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