{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T14:23:33Z","timestamp":1783088613578,"version":"3.54.6"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Health and Labor Science Research Grants of Japan"},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Science, Sports and Culture, Japan","doi-asserted-by":"crossref","award":["24390099"],"award-info":[{"award-number":["24390099"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Ghrelin is a 28\u2010amino\u2010acid peptide that stimulates the release of pituitary growth hormone. Because of its orexigenic effects, ghrelin is being developed as a therapeutic option for postoperative support and treatment of anorexia\u2010cachexia syndrome of cancer patients. However, ghrelin has a multiplicity of physiological functions, and it also affects cell proliferation. Therefore, the effects of ghrelin administration on carcinogenesis and cancer progression in patients susceptible to cancer should be clarified. In this study, we examined the effects of ghrelin on cancer promotion <jats:italic>in\u00a0vivo<\/jats:italic> using murine intestinal carcinogenesis models. Intestinal tumorigenesis was examined to determine the effects of either exogenous ghrelin administration or ghrelin deficiency following deletion of the <jats:italic>Ghrl<\/jats:italic> gene. Two murine intestinal tumorigenesis models were used. The first was the azoxymethane (<jats:styled-content style=\"fixed-case\">AOM<\/jats:styled-content>)\/dextran sodium sulfate (<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>)\u2010induced inflammation\u2010associated colon carcinogenesis model and the second was the <jats:italic>Apc<\/jats:italic><jats:sup>Min\/+<\/jats:sup> genetic cancer susceptibility model. In <jats:styled-content style=\"fixed-case\">AOM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\u2010treated mice, administration of ghrelin significantly suppressed tumor formation in the colon. In contrast, ghrelin administration did not affect the number of intestinal tumors formed in <jats:italic>Apc<\/jats:italic><jats:sup>Min\/+<\/jats:sup> mice. The absence of endogenous ghrelin did not affect the incidence of intestinal tumors in either <jats:styled-content style=\"fixed-case\">AOM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\u2010treated mice or <jats:italic>Apc<\/jats:italic><jats:sup>Min\/+<\/jats:sup> mice, though tumor size tended to be larger in <jats:italic>Ghrl<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> colons in the <jats:styled-content style=\"fixed-case\">AOM<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content> model. No tumor\u2010promoting effect was observed by ghrelin administration in either tumorigenesis model. In summary, this study provides <jats:italic>in\u00a0vivo<\/jats:italic> experimental evidence for the usefulness of ghrelin administration in the chemoprevention of inflammation\u2010associated colorectal carcinogenesis and may suggest its safety in patients under colitis\u2010associated cancer susceptibility conditions.<\/jats:p>","DOI":"10.1111\/cas.12725","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T10:07:12Z","timestamp":1434708432000},"page":"1130-1136","source":"Crossref","is-referenced-by-count":27,"title":["Ghrelin administration suppresses inflammation\u2010associated colorectal carcinogenesis in mice"],"prefix":"10.1111","volume":"106","author":[{"given":"Makiko","family":"Kawaguchi","sequence":"first","affiliation":[{"name":"Section\u00a0of Oncopathology and Regenerative Biology Department of Pathology Faculty of Medicine University of Miyazaki Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Kanemaru","sequence":"additional","affiliation":[{"name":"Section\u00a0of Oncopathology and Regenerative Biology Department of Pathology Faculty of Medicine University of Miyazaki Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Section\u00a0of Oncopathology and Regenerative Biology Department of Pathology Faculty of Medicine University of Miyazaki Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Section\u00a0of Oncopathology and Regenerative Biology Department of Pathology Faculty of Medicine University of Miyazaki Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Section\u00a0of Oncopathology and Regenerative Biology Department of Pathology Faculty of Medicine University of Miyazaki Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Haruyama","sequence":"additional","affiliation":[{"name":"Section\u00a0of Oncopathology and Regenerative Biology Department of Pathology Faculty of Medicine University of Miyazaki Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathology Yamaguchi University Graduate School of Medicine Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Division of Neurology, Respirology, Endocrinology and Metabolism Department of Internal Medicine Faculty of Medicine University of Miyazaki Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Kangawa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry National Cardiovascular Center Research Institute Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Nakazato","sequence":"additional","affiliation":[{"name":"Division of Neurology, Respirology, Endocrinology and Metabolism Department of Internal Medicine Faculty of Medicine University of Miyazaki Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Section\u00a0of Oncopathology and Regenerative Biology Department of Pathology Faculty of Medicine University of Miyazaki Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/45230"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/35051587"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvr134"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000012"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2013.7.5.505"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-014-1040-z"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2008.03.020"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2010.03.011"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00205.2009"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(02)00089-8"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4137\/CGast.S12731"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-012-0352-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.07.032"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathophys.2014.05.002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2007.00695.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000986"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.11.098"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.01.041"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318294711e"},{"key":"e_1_2_7_21_1","first-page":"41","article-title":"Ghrelin ameliorates colonic inflammation. Role of nitric oxide and sensory nerves","volume":"60","author":"Konturek PC","year":"2009","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2007.09.010"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-3337"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.06.038"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06715.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-013-0856-0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(12)70890-3"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1731-6"},{"key":"e_1_2_7_29_1","first-page":"388","article-title":"The role of serum total ghrelin level elevation in colon cancer patients","volume":"19","author":"Nikolopoulos D","year":"2014","journal-title":"J BUON"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9508-3"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.01.083"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.09.025"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12098"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcas.12725","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.12725","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.12725","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.12725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T08:20:33Z","timestamp":1696234833000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.12725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,14]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/cas.12725"],"URL":"https:\/\/doi.org\/10.1111\/cas.12725","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,14]]}}}