{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:30:46Z","timestamp":1787934646306,"version":"build-2784847793"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T00:00:00Z","timestamp":1439424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Peripheral T\u2010cell lymphomas (<jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>) are a heterogeneous group of non\u2010Hodgkin lymphomas with poor prognosis. Their molecular pathogenesis has not been entirely elucidated. We previously showed that 6q24 is one of the most frequently deleted regions in primary thyroid T\u2010cell lymphoma. In this study, we extended the analysis to other subtypes of <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content> and performed functional assays to identify the causative genes of <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content> that are located on 6q24. Genomic loss of 6q24 was observed in 14 of 232 (6%) <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content> cases. The genomic loss regions identified at 6q24 always involved only two known genes, <jats:italic><jats:styled-content style=\"fixed-case\">STX<\/jats:styled-content>11<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">UTRN<\/jats:styled-content><\/jats:italic>. The expression of <jats:styled-content style=\"fixed-case\">STX<\/jats:styled-content>11, but not <jats:styled-content style=\"fixed-case\">UTRN<\/jats:styled-content>, was substantially lower in <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content> than in normal T\u2010cells. <jats:italic><jats:styled-content style=\"fixed-case\">STX<\/jats:styled-content>11<\/jats:italic> sequence analysis revealed mutations in two cases (one clinical sample and one T\u2010cell line). We further analyzed the function of <jats:styled-content style=\"fixed-case\">STX<\/jats:styled-content>11 in 14 cell lines belonging to different lineages. <jats:styled-content style=\"fixed-case\">STX<\/jats:styled-content>11 expression only suppressed the proliferation of T\u2010cell lines bearing genomic alterations at the <jats:italic><jats:styled-content style=\"fixed-case\">STX<\/jats:styled-content>11<\/jats:italic> locus. Interestingly, expression of a novel <jats:styled-content style=\"fixed-case\">STX<\/jats:styled-content>11 mutant (p.Arg78Cys) did not exert suppressive effects on the induced cell lines, suggesting that this mutant is a loss\u2010of\u2010function mutation. In addition, <jats:italic><jats:styled-content style=\"fixed-case\">STX<\/jats:styled-content>11<\/jats:italic>\u2010altered <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content> not otherwise specified cases were characterized by the presence of hemophagocytic syndrome (67% <jats:italic>vs<\/jats:italic> 8%, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0.04). They also tended to have a poor prognosis compared with those without <jats:italic><jats:styled-content style=\"fixed-case\">STX<\/jats:styled-content>11<\/jats:italic> alteration. These results suggest that <jats:styled-content style=\"fixed-case\">STX<\/jats:styled-content>11 plays an important role in the pathogenesis of <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content> and they may contribute to the future development of new drugs for the treatment of <jats:styled-content style=\"fixed-case\">PTCL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cas.12742","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T23:08:58Z","timestamp":1436915338000},"page":"1455-1462","source":"Crossref","is-referenced-by-count":24,"title":["<i><scp>STX<\/scp>11<\/i> functions as a novel tumor suppressor gene in peripheral T\u2010cell lymphomas"],"prefix":"10.1111","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7001-0106","authenticated-orcid":false,"given":"Noriaki","family":"Yoshida","sequence":"first","affiliation":[{"name":"Division of Molecular Medicine Aichi Cancer Center Research Institute Nagoya 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