{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:06:01Z","timestamp":1777583161024,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,25]],"date-time":"2016-01-25T00:00:00Z","timestamp":1453680000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>\n                    Green tea and coffee consumption may decrease the risk of some types of cancers. However, their effects on biliary tract cancer (\n                    <jats:styled-content style=\"fixed-case\">BTC<\/jats:styled-content>\n                    ) have been poorly understood. In this population\u2010based prospective cohort study in Japan, we investigated the association of green tea (total green tea,\n                    <jats:italic>Sencha,<\/jats:italic>\n                    and\n                    <jats:italic>Bancha\/Genmaicha<\/jats:italic>\n                    ) and coffee consumption with the risk for\n                    <jats:styled-content style=\"fixed-case\">BTC<\/jats:styled-content>\n                    and its subtypes, gallbladder cancer, and extrahepatic bile duct cancer. The hazard ratios and 95% confidence intervals were calculated using the Cox proportional hazard model. A total of 89\u00a0555 people aged 45\u201374\u00a0years were enrolled between 1995 and 1999 and followed up for 1\u00a0138\u00a0623 person\u2010years until 2010, during which 284 cases of\n                    <jats:styled-content style=\"fixed-case\">BTC<\/jats:styled-content>\n                    were identified. Consumption of &gt;720\u00a0mL\/day green tea was significantly associated with decreased risk compared with consumption of \u2264120\u00a0mL\/day (hazard ratio\u00a0=\u00a00.67 [95% confidence interval, 0.46\u20130.97]), and a non\u2010significant trend of decreased risk associated with increased consumption was observed (\n                    <jats:italic>P<\/jats:italic>\n                    \u2010trend\u00a0=\u00a00.095). In the analysis according to the location of the primary tumor, consuming &gt;120\u00a0mL green tea tended to be associated with decreased risk of gallbladder cancer and extrahepatic bile duct cancer. When\n                    <jats:italic>Sencha<\/jats:italic>\n                    and\n                    <jats:italic>Bancha\/Genmaicha<\/jats:italic>\n                    were analyzed separately, we observed a non\u2010significant trend of decreased risk of\n                    <jats:styled-content style=\"fixed-case\">BTC<\/jats:styled-content>\n                    associated with\n                    <jats:italic>Sencha<\/jats:italic>\n                    but no association with\n                    <jats:italic>Bancha\/Genmaicha<\/jats:italic>\n                    . For coffee, there was no clear association with biliary tract, gallbladder, or extrahepatic bile duct cancer. Our findings suggest that high green tea consumption may lower the risk of\n                    <jats:styled-content style=\"fixed-case\">BTC<\/jats:styled-content>\n                    , and the effect may be attributable to\n                    <jats:italic>Sencha<\/jats:italic>\n                    consumption.\n                  <\/jats:p>","DOI":"10.1111\/cas.12843","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T03:24:41Z","timestamp":1446607481000},"page":"76-83","source":"Crossref","is-referenced-by-count":40,"title":["Association between green tea\/coffee consumption and biliary tract cancer: A population\u2010based cohort study in Japan"],"prefix":"10.1111","volume":"107","author":[{"given":"Takeshi","family":"Makiuchi","sequence":"first","affiliation":[{"name":"Department of Environmental Medicine and Population Sciences, Graduate School of Medicine Osaka University Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomotaka","family":"Sobue","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine and Population Sciences, Graduate School of Medicine Osaka University Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuhisa","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine and Population Sciences, Graduate School of Medicine Osaka University Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Graduate School of Nutrition Science Sagami Women's University Sagamihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norie","family":"Sawada","sequence":"additional","affiliation":[{"name":"Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening National Cancer Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoki","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening National Cancer Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizuka","family":"Sasazuki","sequence":"additional","affiliation":[{"name":"Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening National Cancer Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiki","family":"Yamaji","sequence":"additional","affiliation":[{"name":"Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening National Cancer Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taichi","family":"Shimazu","sequence":"additional","affiliation":[{"name":"Epidemiology and Prevention Group, Research Center for Cancer 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