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However, little is known about the therapeutic benefits such CML<\/jats:styled-content>\u2010LIC<\/jats:styled-content> targeting therapies might bring to CML<\/jats:styled-content> patients. In this study, we investigated the therapeutic potential of EW<\/jats:styled-content>\u20107197, an orally bioavailable transforming growth factor\u2010\u03b2 signaling inhibitor which has recently been approved as an Investigational New Drug (NIH<\/jats:styled-content>, USA<\/jats:styled-content>), to suppress CML<\/jats:styled-content>\u2010LIC<\/jats:styled-content>s in vivo<\/jats:italic>. Compared to TKI<\/jats:styled-content> treatment alone, administration of TKI<\/jats:styled-content> plus EW<\/jats:styled-content>\u20107197 to CML<\/jats:styled-content>\u2010affected mice significantly delayed disease relapse and prolonged survival. Notably, combined treatment with EW<\/jats:styled-content>\u20107197 plus TKI<\/jats:styled-content> was effective in eliminating CML<\/jats:styled-content>\u2010LIC<\/jats:styled-content>s even if they expressed the TKI<\/jats:styled-content>\u2010resistant T315I mutant BCR<\/jats:styled-content>\u2010ABL<\/jats:styled-content>1<\/jats:italic> oncogene. Collectively, these results indicate that EW<\/jats:styled-content>\u20107197 may be a promising candidate for a new therapeutic that can greatly benefit CML<\/jats:styled-content> patients by working in combination with TKI<\/jats:styled-content>s to eradicate CML<\/jats:styled-content>\u2010LIC<\/jats:styled-content>s.<\/jats:p>","DOI":"10.1111\/cas.12849","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T13:48:39Z","timestamp":1447940919000},"page":"140-148","source":"Crossref","is-referenced-by-count":31,"title":["Novel oral transforming growth factor\u2010\u03b2 signaling inhibitor EW<\/scp>\u20107197 eradicates CML<\/scp>\u2010initiating cells"],"prefix":"10.1111","volume":"107","author":[{"given":"Kazuhito","family":"Naka","sequence":"first","affiliation":[{"name":"Exploratory Project on Cancer Stem Cells Cancer Research Institute Kanazawa University Kanazawa Japan"},{"name":"Department of Stem Cell Biology Research Institute for Radiation 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