{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:02:15Z","timestamp":1768338135043,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Regional lymph node status is an important prognostic indicator of tumor aggressiveness. However, early diagnosis of metastasis using intranodal pressure, at a stage when lymph node size has not changed significantly, has not been investigated. Here, we use an <jats:styled-content style=\"fixed-case\">MXH<\/jats:styled-content>10\/Mo\u2010<jats:italic>lpr<\/jats:italic>\/<jats:italic>lpr<\/jats:italic> mouse model of lymph node metastasis to show that intranodal pressure increases in both the subiliac lymph node and proper axillary lymph node, which are connected by lymphatic vessels, when tumor cells are injected into the subiliac lymph node to induce metastasis to the proper axillary lymph node. We found that intranodal pressure in the subiliac lymph node increased at the stage when metastasis was detected by <jats:italic>in vivo<\/jats:italic> bioluminescence, but when proper axillary lymph node volume (measured by high\u2010frequency ultrasound imaging) had not increased significantly. Intravenously injected liposomes, encapsulating indocyanine green, were detected in solid tumors by <jats:italic>in vivo<\/jats:italic> bioluminescence, but not in the proper axillary lymph node. Basic blood vessel and lymphatic channel structures were maintained in the proper axillary lymph node, although sinus histiocytosis was detected. These results show that intranodal pressure in the proper axillary lymph node increases at early stages when metastatic tumor cells have not fully proliferated. Intranodal pressure may be a useful parameter for facilitating early diagnosis of lymph node metastasis.<\/jats:p>","DOI":"10.1111\/cas.12873","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T14:06:49Z","timestamp":1451484409000},"page":"224-232","source":"Crossref","is-referenced-by-count":24,"title":["Early diagnosis of lymph node metastasis: Importance of intranodal pressures"],"prefix":"10.1111","volume":"107","author":[{"given":"Yoshinobu","family":"Miura","sequence":"first","affiliation":[{"name":"Graduate School of Biomedical Engineering Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Mikada","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Engineering Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoki","family":"Ouchi","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Engineering Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachiko","family":"Horie","sequence":"additional","affiliation":[{"name":"Institute of Development, Aging and Cancer Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazu","family":"Takeda","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Engineering Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teppei","family":"Yamaki","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Engineering Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Tohoku University Hospital Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Mori","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Engineering Tohoku University Sendai Japan"},{"name":"Department of Oral and Maxillofacial Surgery Tohoku University Hospital Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Kodama","sequence":"additional","affiliation":[{"name":"Graduate School of Biomedical Engineering Tohoku University Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.02.060"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0896"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.110.085944"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-4200"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-236"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.125443"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3249-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219603110"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3196"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-0903"},{"key":"e_1_2_7_12_1","first-page":"661","article-title":"Pulmonary and lymph node metastasis is associated with primary tumor interstitial fluid pressure in human melanoma xenografts","volume":"62","author":"Rofstad EK","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2013.01.004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.03.066"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2015.05.007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.6.000124"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2014.12.014"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-2389"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055797"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1796-y"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.10.014"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199507000-00001"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.013"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3186"},{"key":"e_1_2_7_25_1","first-page":"6387","article-title":"A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs","volume":"46","author":"Matsumura Y","year":"1986","journal-title":"Cancer Res"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(92)90136-A"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI15830"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.88.6.623"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.266700"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcas.12873","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.12873","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cas.12873","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cas.12873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T23:40:39Z","timestamp":1696290039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cas.12873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,23]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1111\/cas.12873"],"URL":"https:\/\/doi.org\/10.1111\/cas.12873","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,23]]}}}