{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:26:08Z","timestamp":1791321968548,"version":"4.3.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology","doi-asserted-by":"publisher","award":["25462606"],"award-info":[{"award-number":["25462606"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>Vasohibin\u20101 (<jats:styled-content style=\"fixed-case\">VASH<\/jats:styled-content>1) is a negative feedback regulator of angiogenesis, the first to be discovered, and was identified in vascular endothelial growth factor (<jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>)\u2010stimulated vascular endothelial cells. Vasohibin\u20101 inhibits abnormal vascularization induced by various angiogenic factors including fibroblast growth factor and platelet\u2010derived growth factor (<jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>), in addition to <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>. By focusing on this characteristic of <jats:styled-content style=\"fixed-case\">VASH<\/jats:styled-content>1, we investigated the antitumor effects of <jats:styled-content style=\"fixed-case\">VASH<\/jats:styled-content>1 expression on ovarian cancer cells that produce different angiogenic factors. By using a high <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010producing ovarian cancer cell line, <jats:styled-content style=\"fixed-case\">SHIN<\/jats:styled-content>\u20103, and a high <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>\u2010producing ovarian cancer cell line, <jats:styled-content style=\"fixed-case\">KOC<\/jats:styled-content>\u20102S, the cells were transfected with either a <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> antagonist, soluble <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content> receptor\u20101 (<jats:styled-content style=\"fixed-case\">sVEGFR<\/jats:styled-content>\u20101, or <jats:styled-content style=\"fixed-case\">sF<\/jats:styled-content>lt\u20101), or <jats:styled-content style=\"fixed-case\">VASH<\/jats:styled-content>1 genes to establish their respective cellular expression. The characteristics of these transfectants were compared with controls. We previously reported that the expression of <jats:styled-content style=\"fixed-case\">sF<\/jats:styled-content>lt\u20101 inhibited tumor vascularization and growth of high <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010producing ovarian cancer cells, reduced peritoneal dissemination and ascites development, and prolonged the survival time of the host. However, in the current study, the expression of <jats:styled-content style=\"fixed-case\">sF<\/jats:styled-content>lt\u20101 had no such effect on the high <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>\u2010producing ovarian cancer cells used here, whereas <jats:styled-content style=\"fixed-case\">VASH<\/jats:styled-content>1 expression inhibited tumor vascularization and growth, not only in high <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\u2010producing cells, but also in high <jats:styled-content style=\"fixed-case\">PDGF<\/jats:styled-content>\u2010producing cells, reduced their peritoneal dissemination and ascites, and prolonged the survival time of the host. These results suggest that <jats:styled-content style=\"fixed-case\">VASH<\/jats:styled-content>1 is an effective treatment for ovarian cancer cells that produce different angiogenic factors.<\/jats:p>","DOI":"10.1111\/cas.12911","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T14:18:58Z","timestamp":1455977938000},"page":"629-637","source":"Crossref","is-referenced-by-count":14,"title":["Vasohibin\u20101 expression inhibits advancement of ovarian cancer producing various angiogenic factors"],"prefix":"10.1111","volume":"107","author":[{"given":"Yoshifumi","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Saga","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University Tochigi 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