{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T02:55:43Z","timestamp":1720925743096},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T00:00:00Z","timestamp":1465776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Taiho Pharmaceutical Co., Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Fiber\u2010shaped particles of potassium octatitanate (tradename <jats:styled-content style=\"fixed-case\">TISMO<\/jats:styled-content>; chemical formula K<jats:sub>2<\/jats:sub>O\u00b76TiO<jats:sub>2<\/jats:sub>), which are morphologically similar to asbestos particles, were shown to induce severe proliferative reactions in the pleural mesothelium in a previous experiment carried out over 21 weeks. The present study aims to determine whether these fibers induce malignant mesotheliomas in rodents, and to examine chronic toxicity induced. Additionally, we investigated the specific differences observable between the biological responses to the direct infusion of the fibers alone into the pleural cavity and those induced by the co\u2010administration of the fibers with a known carcinogen. To detect the induction of malignant pleural mesotheliomas, two experiments were undertaken. In Experiment 1, four strains of mice, A\/J, C3H, <jats:styled-content style=\"fixed-case\">ICR<\/jats:styled-content>, and C57<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>, were examined for 52 weeks after experimental treatment with <jats:styled-content style=\"fixed-case\">TISMO<\/jats:styled-content>. In Experiment 2, the F344 rats were treated with <jats:styled-content style=\"fixed-case\">TISMO<\/jats:styled-content> alone, the lung carcinogen <jats:italic>N<\/jats:italic>\u2010bis (2\u2010hydroxypropyl) nitrosamine (<jats:styled-content style=\"fixed-case\">DHPN<\/jats:styled-content>) alone, both <jats:styled-content style=\"fixed-case\">TISMO<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DHPN<\/jats:styled-content>, or left untreated and were then examined for 52 weeks. In this experiment, malignant lesion induction was expected in the co\u2010administration group. <jats:styled-content style=\"fixed-case\">TISMO<\/jats:styled-content> fibers were observed in the alveoli, indicating penetration through the visceral pleura in mice and rats. The histopathological detection of <jats:styled-content style=\"fixed-case\">TISMO<\/jats:styled-content> fibers in the liver and kidneys of mice and rats indicated migration of the fibers out of the pleural cavity. Atypical mesothelial cells with severe pleural proliferation were observed, but malignant mesotheliomas were not detected. Among the rats, there were no observed malignant alterations in the mesothelium induced by <jats:styled-content style=\"fixed-case\">DHPN<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">TISMO<\/jats:styled-content> co\u2010administration.<\/jats:p>","DOI":"10.1111\/cas.12944","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T14:06:39Z","timestamp":1460988399000},"page":"1047-1054","source":"Crossref","is-referenced-by-count":4,"title":["Chronic mesothelial reaction and toxicity of potassium octatitanate fibers in the pleural cavity in mice and F344 rats"],"prefix":"10.1111","volume":"107","author":[{"given":"Masanao","family":"Yokohira","sequence":"first","affiliation":[{"name":"Onco\u2010Pathology Department of Pathology and Host\u2010Defense Faculty of Medicine Kagawa University Kita\u2010gun Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Nakano\u2010Narusawa","sequence":"additional","affiliation":[{"name":"Onco\u2010Pathology Department of Pathology and Host\u2010Defense Faculty of Medicine Kagawa University Kita\u2010gun Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Yamakawa","sequence":"additional","affiliation":[{"name":"Onco\u2010Pathology Department of Pathology and Host\u2010Defense Faculty of Medicine Kagawa University Kita\u2010gun Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Onco\u2010Pathology Department of Pathology and Host\u2010Defense Faculty of Medicine Kagawa University Kita\u2010gun Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Onco\u2010Pathology Department of Pathology and Host\u2010Defense Faculty of Medicine Kagawa University Kita\u2010gun Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Kanie","sequence":"additional","affiliation":[{"name":"Onco\u2010Pathology Department of Pathology and Host\u2010Defense Faculty of Medicine Kagawa University Kita\u2010gun Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Imaida","sequence":"additional","affiliation":[{"name":"Onco\u2010Pathology Department of Pathology and Host\u2010Defense Faculty of Medicine Kagawa University Kita\u2010gun Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.122.6.2224"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67025-0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2005.12.009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annhyg\/mef034"},{"issue":"1","key":"e_1_2_6_6_1","first-page":"19","article-title":"Assessment of carcinogenic effect of aluminosilicate ceramic fibers produced in Poland. 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