{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T15:40:53Z","timestamp":1766504453506},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T00:00:00Z","timestamp":1466553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23590641"],"award-info":[{"award-number":["23590641"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H23\u2010sinkou\u2010ippan\u2010016"],"award-info":[{"award-number":["H23\u2010sinkou\u2010ippan\u2010016"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Adult T\u2010cell leukemia\/lymphoma (<jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>) is an aggressive T\u2010cell malignancy caused by human T\u2010cell lymphotropic virus 1. Treatment options for acute <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> patients include chemotherapy, stem cell transplantation, and recently the anti\u2010chemokine (C\u2010C motif) receptor 4 antibody, although most patients still have a poor prognosis and there is a clear need for additional options. <jats:styled-content style=\"fixed-case\">HBI<\/jats:styled-content>\u20108000 is a novel oral histone deacetylase inhibitor with proven efficacy for treatment of T\u2010cell lymphomas that recently received approval in China. In the present study, we evaluated the effects of <jats:styled-content style=\"fixed-case\">HBI<\/jats:styled-content>\u20108000 on <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>\u2010derived cell lines and primary cells obtained from Japanese <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> patients. In most cases <jats:styled-content style=\"fixed-case\">HBI<\/jats:styled-content>\u20108000 induced apoptosis in both primary <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> cells and cell lines. In addition, findings obtained with <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> microarray suggested Bim activation and, interestingly, the contribution of the <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> family, pyrin domain containing 3 (<jats:styled-content style=\"fixed-case\">NLRP<\/jats:styled-content>3) inflammasome pathway in <jats:styled-content style=\"fixed-case\">HBI<\/jats:styled-content>\u20108000\u2010induced <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> cell death. Further investigations using si<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s confirmed that Bim contributes to <jats:styled-content style=\"fixed-case\">HBI<\/jats:styled-content>\u20108000\u2010induced apoptosis. Our results provide a rationale for a clinical investigation of the efficacy of <jats:styled-content style=\"fixed-case\">HBI<\/jats:styled-content>\u20108000 in patients with <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content>. Although the role of <jats:styled-content style=\"fixed-case\">NLRP<\/jats:styled-content>3 inflammasome activation in <jats:styled-content style=\"fixed-case\">ATL<\/jats:styled-content> cell death remains to be verified, <jats:styled-content style=\"fixed-case\">HBI<\/jats:styled-content>\u20108000 may be part of a novel therapeutic strategy for cancer based on the <jats:styled-content style=\"fixed-case\">NLRP<\/jats:styled-content>3 pathway.<\/jats:p>","DOI":"10.1111\/cas.12971","type":"journal-article","created":{"date-parts":[[2016,5,19]],"date-time":"2016-05-19T17:41:35Z","timestamp":1463679695000},"page":"1124-1133","source":"Crossref","is-referenced-by-count":16,"title":["Induction of apoptosis by HBI\u20108000 in adult T\u2010cell leukemia\/lymphoma is associated with activation of Bim and NLRP3"],"prefix":"10.1111","volume":"107","author":[{"given":"Hiroo","family":"Hasegawa","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Nagasaki University 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