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It arises from the nasopharynx epithelium and is associated with high morbidity and mortality. Long non\u2010coding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>) have been reported to regulate gene interaction and play critical roles in carcinogenesis and progression. Lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content>, a recently identified lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>, has been shown to be involved in initiation, progression and metastasis of several tumors, including hepatocellular carcinoma, breast cancer and glioma. However, whether lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content> is associated with the progression of <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> remains unknown. Resistance to radiotherapy and chemotherapy is the primary cause of <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> patients\u2019 death. In this study, we found that lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content> was significantly upregulated in <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> tissues compared with normal tissues. Next, our study proved that lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content> was highly associated with the proliferation, metastasis and apoptosis of <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content>. The enrichment of lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content> played a critucal functional role in chemoresistance. The mechanism by which <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content> resists chemotherapy might be that lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content> suppress p53 signal pathway. Taken together, these data suggested that lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ROR<\/jats:styled-content> played an important role in the progression of <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content>; thereby it might become a therapeutic target and reduce chemoresistance for <jats:styled-content style=\"fixed-case\">NPC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/cas.12989","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T05:32:48Z","timestamp":1466141568000},"page":"1215-1222","source":"Crossref","is-referenced-by-count":89,"title":["Long non\u2010coding <scp>RNA ROR<\/scp> promotes proliferation, migration and chemoresistance of nasopharyngeal carcinoma"],"prefix":"10.1111","volume":"107","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Affiliated 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University Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Affiliated Hospital of Nantong University Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"You","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery Affiliated Hospital of Nantong University Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110674"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4057"},{"issue":"3","key":"e_1_2_7_4_1","first-page":"388","article-title":"Nasopharyngeal carcinoma","volume":"7","author":"Chua 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