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In this study, by using an <jats:italic>in vivo<\/jats:italic> tumor progression model in which low tumorigenic cancer cells acquire malignant metastatic phenotype after exposure to inflammation, we found that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A is a critical cue for escalating cancer cell malignancy. We further demonstrated that the length of exposure to an inflammatory microenvironment could be associated with acquiring greater tumorigenicity and that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A was critical for amplifying such local inflammation, as observed in the production of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 and neutrophil infiltration following the cross\u2010talk between cancer and host stromal cells. We further determined that \u03b3\u03b4T cells expressing V\u03b41 semi\u2010invariant <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content> initiate cancer\u2010promoting inflammation by producing <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A in an MyD88\/<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023\u2010dependent manner. Finally, we identified <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30 as a key molecule in the inflammatory function of V\u03b41T cells and the blockade of this pathway targeted this cancer immune\u2010escalation process. Collectively, these results reveal the importance of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A\u2010producing <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>30<jats:sup>+<\/jats:sup> V\u03b41T cells in triggering inflammation and orchestrating a microenvironment leading to cancer progression.<\/jats:p>","DOI":"10.1111\/cas.13005","type":"journal-article","created":{"date-parts":[[2016,7,6]],"date-time":"2016-07-06T16:25:50Z","timestamp":1467822350000},"page":"1206-1214","source":"Crossref","is-referenced-by-count":31,"title":["<scp>IL<\/scp>\u201017A\u2010producing <scp>CD<\/scp>30<sup>+<\/sup> V\u03b41 T cells drive inflammation\u2010induced cancer progression"],"prefix":"10.1111","volume":"107","author":[{"given":"Yoshitaka","family":"Kimura","sequence":"first","affiliation":[{"name":"Laboratory of Cancer Biology and Molecular Immunology Graduate School of Pharmaceutical Sciences University of Tokyo Bunkyo\u2010ku Tokyo 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